# vascular endothelial growth factor A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7916455](https://www.wikidata.org/wiki/Q7916455)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Vascular_endothelial_growth_factor_A)  
**Source**: https://4ort.xyz/entity/vascular-endothelial-growth-factor-a


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3707357)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P15692)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/H0YBI8)
5. Q20641742
6. [pH regulates vascular endothelial growth factor binding to fibronectin: a mechanism for control of extracellular matrix storage and release](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
8. [Heparin affin regulatory peptide binds to vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
9. [Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
11. [Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
12. [Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
13. [Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
14. [Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
15. [Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
16. [Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
17. [Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
18. [The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
19. [Vascular endothelial growth factor can signal through platelet-derived growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
20. [MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
21. [Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
22. [Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
23. [Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
24. [Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
25. [Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
26. [Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
27. [Characterization of the VEGF binding site on the Flt-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
28. [Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
29. [Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
30. [Expression and functions of the vascular endothelial growth factors and their receptors in human basophils](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
31. [Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
32. [Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
33. [The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
34. [Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)
35. [Development of a highly-potent anti-angiogenic VEGF8-109 heterodimer by directed blocking of its VEGFR-2 binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
36. [The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
37. [Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
38. [Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
39. [Characterization of the VEGF binding site on the Flt-1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
41. [Vasoactive peptides modulate vascular endothelial cell growth factor production and endothelial cell proliferation and invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
42. [Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
43. [Expression and functions of the vascular endothelial growth factors and their receptors in human basophils](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
44. [The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
45. [Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
46. [The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
47. [Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
48. [Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15692)
49. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H0YBI8)
50. [Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15692&geneProductId=UniProtKB:P15692)