# VANGL planar cell polarity 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21981325](https://www.wikidata.org/wiki/Q21981325)  
**Source**: https://4ort.xyz/entity/vangl-planar-cell-polarity-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q91ZD4)
3. Q20641742
4. [Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
5. [Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
6. [Planar cell polarity pathway regulates actin rearrangement, cell shape, motility, and nephrin distribution in podocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
7. [Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
8. [Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
9. [Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
10. [Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
11. [Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
12. [MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
13. [Vangl2, the planner cell polarity protein, is complexed with postsynaptic density protein PSD‐95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
14. [All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
15. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
16. [Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
17. [Wnt5a functions in planar cell polarity regulation in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
18. [Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
19. [Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: Effect of the Lp mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
20. [Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
21. [Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
23. [Wnt/Planar Cell Polarity Signaling Controls the Anterior–Posterior Organization of Monoaminergic Axons in the Brainstem](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
24. [Ciliary proteins link basal body polarization to planar cell polarity regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
25. [The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
26. [Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
27. [Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
28. [Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
29. [Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
30. [Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
31. [Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
32. [Identification of Vangl2 and Scrb1 as planar polarity genes in mammals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
33. [Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
34. [Epidermal wound repair is regulated by the planar cell polarity signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
35. [The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
36. [Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
37. [Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
38. [The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
39. [Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
40. [Cardiovascular defects associated with abnormalities in midline development in the Loop-tail mouse mutant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
41. [Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
42. [Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
43. [Cordon-bleu is a conserved gene involved in neural tube formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
44. [PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
45. [Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
46. [Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
47. [The Role of Frizzled3 and Frizzled6 in Neural Tube Closure and in the Planar Polarity of Inner-Ear Sensory Hair Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
48. [Asymmetric Distribution of Prickle-Like 2 Reveals an Early Underlying Polarization of Vestibular Sensory Epithelia in the Inner Ear](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
49. [PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)
50. [Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q91ZD4)