# Valosin containing protein

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109279](https://www.wikidata.org/wiki/Q21109279)  
**Source**: https://4ort.xyz/entity/valosin-containing-protein-q21109279


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P55072)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
5. [A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55072&geneProductId=UniProtKB:P55072)
7. [Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P55072&geneProductId=UniProtKB:P55072)
8. [DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
9. [Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
10. [Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
11. [Lysine methylation of VCP by a member of a novel human protein methyltransferase family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
12. [Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
13. [The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
14. [VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
15. [Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
16. [Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
17. [A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
18. [Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
19. [UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
20. [Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
21. [Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
22. [VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
23. [Human Fas-associated factor 1, interacting with ubiquitinated proteins and valosin-containing protein, is involved in the ubiquitin-proteasome pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
24. [The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
25. [The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
26. [A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
27. [Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
28. [ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
29. [The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
30. [DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
31. [The UBX Protein SAKS1 Negatively Regulates Endoplasmic Reticulum-associated Degradation and p97-dependent Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
32. [Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
33. [Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
34. [Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
35. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
36. [Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
37. [NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
38. [Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
39. [The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
40. [Hierarchical binding of cofactors to the AAA ATPase p97](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
41. [Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
42. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
43. [Imbalances in p97 co-factor interactions in human proteinopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
44. [Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
45. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
46. [ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
47. [UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
48. [Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
49. [Ubxd1 is a novel co-factor of the human p97 ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)
50. [The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P55072)