# UPF2 regulator of nonsense mediated mRNA decay

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21124873](https://www.wikidata.org/wiki/Q21124873)  
**Source**: https://4ort.xyz/entity/upf2-regulator-of-nonsense-mediated-mrna-decay


## References

1. UniProt
2. Q20641742
3. [SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
4. [The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
5. [Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
6. [Human INT6/eIF3e is required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
7. [NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
8. [Results of the determination of serum markers in patients with malignant melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
9. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
10. [AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
11. [Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
12. [Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
13. [Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
14. [SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
15. [Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
16. [A protein interaction framework for human mRNA degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
17. [Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
18. [A UPF3-mediated regulatory switch that maintains RNA surveillance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
19. [Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
20. [The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
21. [Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
22. [Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
23. [Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
24. [The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
25. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
26. [Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
27. [Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
28. [Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
29. [The human RNA surveillance factor UPF1 is required for S phase progression and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
30. [Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
31. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
33. [Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
34. [Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
35. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
37. [Human INT6/eIF3e is required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
38. [The human RNA surveillance factor UPF1 is required for S phase progression and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
39. [NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9HAU5&geneProductId=UniProtKB:Q9HAU5)
40. [NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9HAU5)
41. Ensembl Release 99