# UPF1 RNA helicase and ATPase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21104922](https://www.wikidata.org/wiki/Q21104922)  
**Source**: https://4ort.xyz/entity/upf1-rna-helicase-and-atpase


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92900)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
6. [Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
7. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
8. [The human RNA surveillance factor UPF1 is required for S phase progression and genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
9. [MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
10. [The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
11. [The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
12. [SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
13. [Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
14. [Regnase-1 and Roquin regulate inflammatory mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
15. [Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
16. [Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
17. [Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
18. [Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
19. [SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
20. [Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
21. [The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
22. [Human INT6/eIF3e is required for nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
23. [Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
24. [The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
25. [Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
26. [Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
27. [Results of the determination of serum markers in patients with malignant melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
28. [Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
29. [Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
30. [Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
31. [Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
32. [An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
33. [Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
34. [Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
35. [A UPF3-mediated regulatory switch that maintains RNA surveillance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
36. [Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
37. [A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
38. [Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
39. [Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
40. [Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
41. [Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
42. [Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900)
43. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900)
44. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900)
45. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900)
46. [Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
47. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
48. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
49. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900)
50. [Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900)