Unc-93 homolog B1, TLR signaling regulator
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Ion channel regulatory protein, UNC-93
additional property: PropertyValue
  property ID: P637
  value: NP_001154900
additional property: PropertyValue
  property ID: P637
  value: NP_062322
additional property: PropertyValue
  property ID: P637
  value: XP_006531861
additional property: PropertyValue
  property ID: P680
  value: Toll-like receptor binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: Toll-like receptor binding
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum membrane
additional property: PropertyValue
  property ID: P682
  value: antigen processing and presentation
additional property: PropertyValue
  property ID: P682
  value: adaptive immune response
additional property: PropertyValue
  property ID: P682
  value: antigen processing and presentation of exogenous peptide antigen via MHC class II
additional property: PropertyValue
  property ID: P702
  value: Unc93b1
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000124272
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000128751
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 16
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 16
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q8VCW4
    source count: 1
    confidence: 0.2
  P361:
    value: Q24739774
    source count: 1
    confidence: 0.2
    value label: Ion channel regulatory protein, UNC-93
  P637:
    value: NP_001154900
    source count: 1
    confidence: 0.2
  P637:
    value: NP_062322
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006531861
    source count: 1
    confidence: 0.2
  P680:
    value: Q21117389
    source count: 1
    confidence: 0.2
    value label: Toll-like receptor binding
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q21117389
    source count: 2
    confidence: 0.4
    value label: Toll-like receptor binding
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q824237
    source count: 3
    confidence: 0.6
    value label: endosome
  P681:
    value: Q14329032
    source count: 1
    confidence: 0.2
    value label: endoplasmic reticulum membrane
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14907320
    source count: 1
    confidence: 0.2
    value label: early phagosome
  P682:
    value: Q14876119
    source count: 1
    confidence: 0.2
    value label: antigen processing and presentation
  P682:
    value: Q14887714
    source count: 1
    confidence: 0.2
    value label: adaptive immune response
  P682:
    value: Q14876758
    source count: 1
    confidence: 0.2
    value label: antigen processing and presentation of exogenous peptide antigen via MHC class II
  P682:
    value: Q14916317
    source count: 1
    confidence: 0.2
    value label: immune system process
  P682:
    value: Q14864542
    source count: 1
    confidence: 0.2
    value label: toll-like receptor signaling pathway
  P702:
    value: Q18258139
    source count: 1
    confidence: 0.2
    value label: Unc93b1
  P703:
    value: Q83310
    source count: 1
    confidence: 0.2
    value label: house mouse
  P705:
    value: ENSMUSP00000124272
    source count: 1
    confidence: 0.2
  P705:
    value: ENSMUSP00000128751
    source count: 1
    confidence: 0.2
citations:
  source: The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
  stated in qid: Q28590478
  retrieved: 2018-03-27
citations:
  source: Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
  stated in qid: Q29347250
  retrieved: 2019-02-14
citations:
  source: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
  stated in qid: Q24337463
  retrieved: 2019-02-14
citations:
  source: The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
  stated in qid: Q28590478
  retrieved: 2019-02-14
citations:
  source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
  stated in qid: Q34211397
  retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-03-27

source: UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
stated in qid: Q28270473
retrieved: 2018-03-27

source: The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
stated in qid: Q28292044
retrieved: 2018-03-27

source: UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
stated in qid: Q28270473
retrieved: 2019-02-14

source: The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
stated in qid: Q28292044
retrieved: 2019-02-14

source: Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
stated in qid: Q28512098
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2018-09-12

source: Q20641742
stated in qid: Q20641742
retrieved: 2019-03-18

source: ensembl Release 95
stated in qid: Q60629863

wikidata id: Q21983783
domain: protein
level: standard
html url: https://4ort.xyz/entity/unc-93-homolog-b1-tlr-signaling-regulator-q21983783
markdown url: https://4ort.xyz/entity/unc-93-homolog-b1-tlr-signaling-regulator-q21983783.md
facts url summary: https://4ort.xyz/entity/unc-93-homolog-b1-tlr-signaling-regulator-q21983783/facts.json
facts url standard: https://4ort.xyz/entity/unc-93-homolog-b1-tlr-signaling-regulator-q21983783/facts.json
facts url full: https://4ort.xyz/entity/unc-93-homolog-b1-tlr-signaling-regulator-q21983783/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-10T13:09:12.439726Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:26:07.980114+00:00Z