# Unc-51 like autophagy activating kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21116760](https://www.wikidata.org/wiki/Q21116760)  
**Source**: https://4ort.xyz/entity/unc-51-like-autophagy-activating-kinase-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O75385)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
6. [Human ULK1, a Novel Serine/Threonine Kinase Related to UNC-51 Kinase ofCaenorhabditis elegans:cDNA Cloning, Expression, and Chromosomal Assignment](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
7. [Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
8. [FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
9. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
10. [TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
11. [Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
12. [TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
13. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
14. [WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
15. [IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
16. [Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
17. [Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
18. [FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
19. [Huntingtin functions as a scaffold for selective macroautophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
20. [Network organization of the human autophagy system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
21. [FIP200 regulates targeting of Atg16L1 to the isolation membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
22. [The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
23. [AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
24. [Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex: Recognition and Interaction Mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
25. [Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
26. [Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
27. [mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
28. [Atg101, a novel mammalian autophagy protein interacting with Atg13](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
29. [TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
30. [The Association of AMPK with ULK1 Regulates Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
31. [The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
32. [Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
33. [Genome‐wide siRNA screen reveals amino acid starvation‐induced autophagy requires SCOC and WAC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
34. [Human ULK1, a Novel Serine/Threonine Kinase Related to UNC-51 Kinase ofCaenorhabditis elegans:cDNA Cloning, Expression, and Chromosomal Assignment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
35. [Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
36. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
37. [Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O75385&geneProductId=UniProtKB:O75385)
38. [Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
39. [siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
40. [Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
41. [Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
42. [Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75385)
43. Ensembl Release 99