Unc-5 netrin receptor C
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O95185
additional property: PropertyValue
  property ID: P361
  value: Immunoglobulin-like fold
additional property: PropertyValue
  property ID: P361
  value: Thrombospondin type-1 (TSP1) repeat superfamily
additional property: PropertyValue
  property ID: P361
  value: Death-like domain superfamily
additional property: PropertyValue
  property ID: P527
  value: ZU5 domain
additional property: PropertyValue
  property ID: P527
  value: Thrombospondin type-1 (TSP1) repeat
additional property: PropertyValue
  property ID: P527
  value: death domain
additional property: PropertyValue
  property ID: P637
  value: NP_003719
additional property: PropertyValue
  property ID: P637
  value: XP_005263378
additional property: PropertyValue
  property ID: P637
  value: XP_016864278
additional property: PropertyValue
  property ID: P680
  value: netrin receptor activity
additional property: PropertyValue
  property ID: P680
  value: netrin receptor activity involved in chemorepulsion
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: neuron projection
additional property: PropertyValue
  property ID: P681
  value: cell junction
additional property: PropertyValue
  property ID: P682
  value: positive regulation of apoptotic process
additional property: PropertyValue
  property ID: P682
  value: netrin-activated signaling pathway
additional property: PropertyValue
  property ID: P682
  value: multicellular organism development
additional property: PropertyValue
  property ID: P702
  value: UNC5C
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000406022
additional property: PropertyValue
  property ID: P705
  value: ENSP00000426153
additional property: PropertyValue
  property ID: P705
  value: ENSP00000425117
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:O95185
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/O95185
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/O95185
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 14
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 14
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O95185
    source count: 1
    confidence: 0.2
  P361:
    value: Q24787648
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like fold
  P361:
    value: Q41797497
    source count: 1
    confidence: 0.2
    value label: Thrombospondin type-1 (TSP1) repeat superfamily
  P361:
    value: Q24776395
    source count: 1
    confidence: 0.2
    value label: Death-like domain superfamily
  P361:
    value: Q41797304
    source count: 1
    confidence: 0.2
    value label: Immunoglobulin-like domain superfamily
  P361:
    value: Q54460533
    source count: 1
    confidence: 0.2
    value label: Netrin receptor UNC5
  P527:
    value: Q24773892
    source count: 1
    confidence: 0.2
    value label: ZU5 domain
  P527:
    value: Q24772391
    source count: 1
    confidence: 0.2
    value label: Thrombospondin type-1 (TSP1) repeat
  P527:
    value: Q5247322
    source count: 1
    confidence: 0.2
    value label: death domain
  P527:
    value: Q24774513
    source count: 1
    confidence: 0.2
    value label: immunoglobulin subtype 2
  P527:
    value: Q24783253
    source count: 1
    confidence: 0.2
    value label: immunoglobulin-like domain
  P637:
    value: NP_003719
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005263378
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016864278
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016864279
    source count: 1
    confidence: 0.2
  P680:
    value: Q14905671
    source count: 3
    confidence: 0.6
    value label: netrin receptor activity
  P680:
    value: Q22243883
    source count: 2
    confidence: 0.4
    value label: netrin receptor activity involved in chemorepulsion
  P680:
    value: Q167149
    source count: 1
    confidence: 0.2
    value label: protein binding
  P680:
    value: Q14817984
    source count: 1
    confidence: 0.2
    value label: protein kinase binding
  P680:
    value: Q14762993
    source count: 2
    confidence: 0.4
    value label: tubulin binding

value: Q14327652
source count: 2
confidence: 0.4
value label: integral component of membrane

value: Q14645640
source count: 1
confidence: 0.2
value label: neuron projection

value: Q189073
source count: 1
confidence: 0.2
value label: cell junction

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q187181
source count: 1
confidence: 0.2
value label: synapse

value: Q14818063
source count: 1
confidence: 0.2
value label: positive regulation of apoptotic process

value: Q14905676
source count: 2
confidence: 0.4
value label: netrin-activated signaling pathway

value: Q14645705
source count: 1
confidence: 0.2
value label: multicellular organism development

value: Q14330969
source count: 2
confidence: 0.4
value label: brain development

value: Q14860833
source count: 1
confidence: 0.2
value label: regulation of cell migration

value: Q18033169
source count: 1
confidence: 0.2
value label: UNC5C

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000406022
source count: 1
confidence: 0.2

value: ENSP00000426153
source count: 1
confidence: 0.2

value: ENSP00000425117
source count: 1
confidence: 0.2

value: ENSP00000426924
source count: 1
confidence: 0.2

value: ENSP00000483905
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:O95185
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/O95185
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/O95185
source count: 1
confidence: 0.2

source: Cloning and mapping of the UNC5C gene to human chromosome 4q21-q23
stated in qid: Q28115846
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse
stated in qid: Q36137493
retrieved: 2019-05-09

source: An Alzheimer Disease-linked Rare Mutation Potentiates Netrin Receptor Uncoordinated-5C-induced Signaling That Merges with Amyloid β Precursor Protein Signaling
stated in qid: Q38779044
retrieved: 2019-05-09

source: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion
stated in qid: Q38797001
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
stated in qid: Q30616995
retrieved: 2019-05-09

source: Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
stated in qid: Q28118661
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: Identifiers.org
stated in qid: Q16335163

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21122909
domain: protein
level: standard
html url: https://4ort.xyz/entity/unc-5-netrin-receptor-c
markdown url: https://4ort.xyz/entity/unc-5-netrin-receptor-c.md
facts url summary: https://4ort.xyz/entity/unc-5-netrin-receptor-c/facts.json
facts url standard: https://4ort.xyz/entity/unc-5-netrin-receptor-c/facts.json
facts url full: https://4ort.xyz/entity/unc-5-netrin-receptor-c/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T05:07:51.194681Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z