# Ubiquitin specific peptidase 7

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109614](https://www.wikidata.org/wiki/Q21109614)  
**Source**: https://4ort.xyz/entity/ubiquitin-specific-peptidase-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q93009)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
5. [USP10 regulates p53 localization and stability by deubiquitinating p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
6. [FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
7. [USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
8. [Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
9. [Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
10. [The ubiquitin ligase RNF220 enhances canonical Wnt signaling through USP7-mediated deubiquitination of β-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
11. [Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
12. [Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
13. [Critical role for Daxx in regulating Mdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
14. [The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
15. [USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
16. [UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
17. [A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
18. [Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
19. [Monoubiquitylation promotes mitochondrial p53 translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
20. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
21. [The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
22. [Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
23. [Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
24. [Molecular recognition of p53 and MDM2 by USP7/HAUSP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
25. [HAUSP, a novel deubiquitinase for Rb – MDM2 the critical regulator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
26. [A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
27. [The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
28. [The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
29. [Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
30. [Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
31. [TSPYL5 suppresses p53 levels and function by physical interaction with USP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
32. [Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
33. [Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
34. [Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
35. [Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
36. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
37. [The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
38. [The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
39. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
40. [A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
41. [Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
42. [The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
43. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
44. [Deubiquitinating enzymes: a new class of biological regulators](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q93009&geneProductId=UniProtKB:Q93009)
45. [The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
46. [Deubiquitinating enzymes: a new class of biological regulators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
47. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
48. [A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
49. [FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)
50. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q93009)