# Ubiquitin protein ligase E3A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q14878332](https://www.wikidata.org/wiki/Q14878332)  
**Source**: https://4ort.xyz/entity/ubiquitin-protein-ligase-e3a-q14878332


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q05086)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
5. [The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
6. [Protein microarray characterization of the S-nitrosoproteome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
7. [The E3 ubiquitin ligase UBE3A is an integral component of the molecular circadian clock through regulating the BMAL1 transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
8. [WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
9. [Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
10. [Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
11. [Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
12. [Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
13. [Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
14. [Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
15. [Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
16. [Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
17. [Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
18. [Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
19. [VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
20. [A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05086&geneProductId=UniProtKB:Q05086)
22. [The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05086&geneProductId=UniProtKB:Q05086)
23. [The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
24. [UBE3A/E6-AP mutations cause Angelman syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
25. [E6AP ubiquitin ligase mediates ubiquitylation and degradation of hepatitis C virus core protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05086)
27. Ensembl Release 99