# Ubiquitin conjugating enzyme E2 N

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21131847](https://www.wikidata.org/wiki/Q21131847)  
**Source**: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-n


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P61088)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
6. [ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
7. [The E3 ligase RNF8 regulates KU80 removal and NHEJ repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
8. [The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
9. [The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
10. [A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
11. [Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
12. [Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
13. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
14. [A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
15. [The MEKK 1 PHD ubiquitinates TAB 1 to activate MAPK s in response to cytokines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
16. [Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
17. [The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
18. [An organelle-specific protein landscape identifies novel diseases and molecular mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
19. [Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
20. [Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
21. [A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
22. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
23. [E2 interaction and dimerization in the crystal structure of TRAF6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
24. [Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
25. [The mechanism of OTUB1-mediated inhibition of ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
26. [Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
27. [Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
28. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
29. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
30. [The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
31. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
32. [The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
34. [Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
35. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
36. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
37. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
38. [The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
39. [Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
40. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
41. [MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
42. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
43. [A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
44. [The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
45. [Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
46. [TRIM5 is an innate immune sensor for the retrovirus capsid lattice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)
47. [Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
48. [A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
49. [Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61088)
50. [The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P61088&geneProductId=UniProtKB:P61088)