# Ubiquitin conjugating enzyme E2 L3

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130015](https://www.wikidata.org/wiki/Q21130015)  
**Source**: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-l3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P68036)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
5. [The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
6. [Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
7. [A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
8. [Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
9. [UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
10. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
11. [Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
12. [UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
13. [The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
14. [The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
15. [Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
16. [TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
17. [Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
18. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
19. [NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
20. [Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
21. [E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
22. [Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
23. [A human protein-protein interaction network: a resource for annotating the proteome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
24. [Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
25. [Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
26. [Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
27. [Insights into RNA biology from an atlas of mammalian mRNA-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
28. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
29. [Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
30. [Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
31. [High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P68036&geneProductId=UniProtKB:P68036)
32. Ensembl Release 99