# Ubiquitin conjugating enzyme E2 I

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130684](https://www.wikidata.org/wiki/Q21130684)  
**Source**: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-i


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63279)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
5. [SUMO-1 modification activates the transcriptional response of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
6. [Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
7. [Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63279&geneProductId=UniProtKB:P63279)
9. [Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the Steroidogenic Acute Regulatory gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
10. [MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
11. [In silico structural and functional characterization of the RSUME splice variants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
12. [A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
13. [The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
14. [Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
15. [Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
16. [Ribosomal protein S3 is stabilized by sumoylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
17. [SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
18. [SUMOylation and SUMO-interacting Motif (SIM) of Metastasis Tumor Antigen 1 (MTA1) Synergistically Regulate Its Transcriptional Repressor Function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
19. [SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
20. [SUMOylation enhances DNA methyltransferase 1 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
21. [SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
22. [Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
23. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
24. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
25. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
26. [Bovine papillomavirus E1 protein is sumoylated by the host cell Ubc9 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
27. [A physical interaction network of dengue virus and human proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
28. [Protein interaction analysis of senataxin and the ALS4 L389S mutant yields insights into senataxin post-translational modification and uncovers mutant-specific binding with a brain cytoplasmic RNA-encoded peptide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
29. [RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
30. [Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
31. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
32. [Inducible SUMO modification of TANK alleviates its repression of TLR7 signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
33. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
34. [Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
35. [Structural basis for the nuclear export activity of Importin13](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
36. [A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
37. [An extended consensus motif enhances the specificity of substrate modification by SUMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
38. [Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
39. [Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
40. [Sumoylation of the SOX10 transcription factor regulates its transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
41. [Interaction of Daxx, a Fas binding protein, with sentrin and Ubc9](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
42. [An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
43. [Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
44. [SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
45. [A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
46. [Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
47. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
48. [Dnmt3b, de Novo DNA Methyltransferase, Interacts with SUMO-1 and Ubc9 through Its N-Terminal Region and Is Subject to Modification by SUMO-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
49. [Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)
50. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63279)