Ubiquitin conjugating enzyme E2 D2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P62837
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-conjugating enzyme/RWD-like
additional property: PropertyValue
  property ID: P361
  value: Peroxisomal Protein Importer
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-conjugating enzyme E2 family
additional property: PropertyValue
  property ID: P527
  value: Ubiquitin-conjugating enzyme E2
additional property: PropertyValue
  property ID: P527
  value: Ubiquitin-conjugating enzyme, active site
additional property: PropertyValue
  property ID: P591
  value: 2.3.2.24
additional property: PropertyValue
  property ID: P637
  value: NP_003330
additional property: PropertyValue
  property ID: P637
  value: NP_862821
additional property: PropertyValue
  property ID: P637
  value: XP_016865309
additional property: PropertyValue
  property ID: P638
  value: 1UR6
additional property: PropertyValue
  property ID: P638
  value: 1W4U
additional property: PropertyValue
  property ID: P638
  value: 2CLW
additional property: PropertyValue
  property ID: P680
  value: transferase activity
additional property: PropertyValue
  property ID: P680
  value: nucleotide binding
additional property: PropertyValue
  property ID: P680
  value: ubiquitin-protein transferase activity
additional property: PropertyValue
  property ID: P681
  value: cytosol
additional property: PropertyValue
  property ID: P681
  value: ubiquitin ligase complex
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P682
  value: ubiquitin-dependent protein catabolic process
additional property: PropertyValue
  property ID: P682
  value: protein polyubiquitination
additional property: PropertyValue
  property ID: P682
  value: stimulatory C-type lectin receptor signaling pathway
additional property: PropertyValue
  property ID: P702
  value: UBE2D2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000381717
additional property: PropertyValue
  property ID: P705
  value: ENSP00000381718
additional property: PropertyValue
  property ID: P705
  value: ENSP00000424941
additional property: PropertyValue
  property ID: P7260
  value: 3.A.20.1.1
confidence:
  popularity graph score:
    score: 0.006
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 46
      unique citations norm: 0.018
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 46
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P62837
    source count: 1
    confidence: 0.2
  P361:
    value: Q24724265
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-conjugating enzyme/RWD-like
  P361:
    value: Q76970795
    source count: 1
    confidence: 0.2
    value label: Peroxisomal Protein Importer
  P361:
    value: Q83134461
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-conjugating enzyme E2 family
  P361:
    value: Q95353694
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-conjugating enzyme, active site, protein family
  P527:
    value: Q24723474
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-conjugating enzyme E2
  P527:
    value: Q24723561
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-conjugating enzyme, active site
  P591:
    value: 2.3.2.24
    source count: 1
    confidence: 0.2
  P637:
    value: NP_003330
    source count: 1
    confidence: 0.2
  P637:
    value: NP_862821
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016865309
    source count: 1
    confidence: 0.2
  P638:
    value: 1UR6
    source count: 1
    confidence: 0.2
  P638:
    value: 1W4U
    source count: 1
    confidence: 0.2
  P638:
    value: 2CLW
    source count: 1
    confidence: 0.2
  P638:
    value: 2ESK
    source count: 1
    confidence: 0.2
  P638:
    value: 2ESO
    source count: 1
    confidence: 0.2
  P680:
    value: Q14840131
    source count: 1
    confidence: 0.2
    value label: transferase activity
  P680:
    value: Q14860365
    source count: 1
    confidence: 0.2
    value label: nucleotide binding
  P680:
    value: Q14860441
    source count: 4
    confidence: 0.8
    value label: ubiquitin-protein transferase activity
  P680:
    value: Q167149
    source count: 18
    confidence: 1.0
    value label: protein binding

value: Q14817981
source count: 1
confidence: 0.2
value label: ATP binding

value: Q220599
source count: 1
confidence: 0.2
value label: cytosol

value: Q14860429
source count: 1
confidence: 0.2
value label: ubiquitin ligase complex

value: Q14817956
source count: 1
confidence: 0.2
value label: nucleoplasm

value: Q903634
source count: 1
confidence: 0.2
value label: extracellular exosome

value: Q14860429
source count: 2
confidence: 0.4
value label: ubiquitin ligase complex

value: Q14864233
source count: 1
confidence: 0.2
value label: ubiquitin-dependent protein catabolic process

value: Q14863376
source count: 1
confidence: 0.2
value label: protein polyubiquitination

value: Q21095173
source count: 1
confidence: 0.2
value label: stimulatory C-type lectin receptor signaling pathway

value: Q14866218
source count: 1
confidence: 0.2
value label: TRIF-dependent toll-like receptor signaling pathway

value: Q14874299
source count: 1
confidence: 0.2
value label: Fc-epsilon receptor signaling pathway

value: Q18032255
source count: 1
confidence: 0.2
value label: UBE2D2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000381717
source count: 1
confidence: 0.2

value: ENSP00000381718
source count: 1
confidence: 0.2

value: ENSP00000424941
source count: 1
confidence: 0.2

value: ENSP00000429613
source count: 1
confidence: 0.2

value: ENSP00000253815
source count: 1
confidence: 0.2

value: 3.A.20.1.1
source count: 2
confidence: 0.4

source: Swiss-Prot
stated in qid: Q2629752
retrieved: 2015-11-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53
stated in qid: Q24321129
retrieved: 2019-04-08

source: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines
stated in qid: Q24294518
retrieved: 2019-04-08

source: Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor
stated in qid: Q24313588
retrieved: 2019-04-08

source: Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation
stated in qid: Q24323309
retrieved: 2019-04-08

source: Molecular basis of Pirh2-mediated p53 ubiquitylation
stated in qid: Q24319435
retrieved: 2019-04-08

source: An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair
stated in qid: Q24314049
retrieved: 2019-04-08

source: A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95
stated in qid: Q24319875
retrieved: 2019-04-08

source: E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis
stated in qid: Q24321714
retrieved: 2019-04-08

source: Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
stated in qid: Q24621898
retrieved: 2019-04-08

source: FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1
stated in qid: Q28117562
retrieved: 2019-04-08

source: Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region
stated in qid: Q24301622
retrieved: 2019-04-08

source: Defining the human deubiquitinating enzyme interaction landscape
stated in qid: Q24315885
retrieved: 2019-04-08

source: Functional proteomics mapping of a human signaling pathway
stated in qid: Q24298398
retrieved: 2019-04-08

source: Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
stated in qid: Q24298615
retrieved: 2019-04-08

source: A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system
stated in qid: Q24336529
retrieved: 2019-04-08

source: Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
stated in qid: Q27676126
retrieved: 2019-04-08

source: Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4
stated in qid: Q27663996
retrieved: 2019-04-08

source: Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates
stated in qid: Q27659805
retrieved: 2019-04-08

source: Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
stated in qid: Q36869071
retrieved: 2019-04-08

source: Turning the RING domain protein MdmX into an active ubiquitin-protein ligase
stated in qid: Q24295055
retrieved: 2019-04-08

source: Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
stated in qid: Q24338947
retrieved: 2019-04-08

source: BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
stated in qid: Q27671574
retrieved: 2019-04-08

source: Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress
stated in qid: Q24306658
retrieved: 2017-10-31

source: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
stated in qid: Q24298901
retrieved: 2017-10-31

source: The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines
stated in qid: Q24294518
retrieved: 2017-10-31

source: Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis
stated in qid: Q24336869
retrieved: 2017-10-31

source: Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
stated in qid: Q24299024
retrieved: 2017-10-31

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

wikidata id: Q21130841
domain: protein
level: standard
html url: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2
markdown url: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2.md
facts url summary: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2/facts.json
facts url standard: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2/facts.json
facts url full: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T11:40:08.484554Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:25:14.046139+00:00Z