# Ubiquitin conjugating enzyme E2 D2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21130841](https://www.wikidata.org/wiki/Q21130841)  
**Source**: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P62837)
3. [Swiss-Prot](http://www.uniprot.org/uniprot/P62837.txt?version=137)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
6. [Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
7. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
8. [Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
9. [Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
10. [Molecular basis of Pirh2-mediated p53 ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
11. [An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
12. [A cancer-associated RING finger protein, RNF43, is a ubiquitin ligase that interacts with a nuclear protein, HAP95](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
13. [E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
14. [Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
15. [FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
16. [Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
17. [Defining the human deubiquitinating enzyme interaction landscape](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
18. [Functional proteomics mapping of a human signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
19. [Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
20. [A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
21. [Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
22. [Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
23. [Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
24. [Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
25. [Turning the RING domain protein MdmX into an active ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
26. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
27. [BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
28. [Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
29. [Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
30. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
31. [Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
32. [Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
33. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
34. [Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
35. [Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
36. [Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
37. [Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
38. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
39. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
40. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
41. [Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
42. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P62837&geneProductId=UniProtKB:P62837)
43. [Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
44. [Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62837)
45. Ensembl Release 99
46. Transporter Classification database