# Ubiquitin conjugating enzyme E2 D1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120023](https://www.wikidata.org/wiki/Q21120023)  
**Source**: https://4ort.xyz/entity/ubiquitin-conjugating-enzyme-e2-d1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51668)
3. [Swiss-Prot](http://www.uniprot.org/uniprot/P51668.txt?version=153)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
7. [CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
8. [Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
9. [The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
10. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
11. [Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
12. [A C2HC zinc finger is essential for the RING-E2 interaction of the ubiquitin ligase RNF125](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
13. [MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
14. [FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
15. [Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
16. [Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
17. [Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
18. [A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
19. [Next-generation sequencing to generate interactome datasets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
20. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
21. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
22. [Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
23. [Mechanism of ubiquitylation by dimeric RING ligase RNF4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
24. [Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
26. [CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
27. [Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
28. [The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
29. [The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
30. [Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
31. [Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
32. [The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
33. [ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
34. [The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
35. [Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
36. [The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51668&geneProductId=UniProtKB:P51668)
37. [Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51668)
38. Ensembl Release 99