# ubiquitin C

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21111827](https://www.wikidata.org/wiki/Q21111827)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Ubiquitin_C)  
**Source**: https://4ort.xyz/entity/ubiquitin-c


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P0CG48)
3. Q20641742
4. [Ubiquitin is a novel substrate for human insulin-degrading enzyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
5. [Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
6. [BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
7. [SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
8. [Monoubiquitylation promotes mitochondrial p53 translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
9. [The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
10. [Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
11. [Phosphorylation of NBR1 by GSK3 modulates protein aggregation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
12. [The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
13. [PARP-1 transcriptional activity is regulated by sumoylation upon heat shock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
14. [Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
15. [The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
16. [Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
17. [The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
18. [Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
19. [CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
20. [Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
21. [Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
22. [Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
23. [COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
24. [Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
25. [Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
26. [Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
27. [NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
28. [Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
29. [A novel ubiquitin-binding protein ZNF216 functioning in muscle atrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
30. [RYBP stabilizes p53 by modulating MDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
31. [HSV-1 ICP27 suppresses NF-kappaB activity by stabilizing IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
32. [CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
33. [The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
34. [Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
35. [Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
36. [The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
37. [A human MAP kinase interactome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
38. [Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
39. [p53 mediates the negative regulation of MDM2 by orphan receptor TR3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
40. [Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
41. [CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
42. [Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
43. [Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
44. [Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
45. [Ubiquitin-mediated proteolysis of HuR by heat shock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
46. [Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
47. [Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
48. [The Polycomb-associated protein Rybp is a ubiquitin binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
49. [MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)
50. [Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P0CG48)