Ubiquilin 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: UBA-like superfamily
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-associated domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Ubiquitin domain
additional property: PropertyValue
  property ID: P527
  value: Heat shock chaperonin-binding
additional property: PropertyValue
  property ID: P527
  value: Ubiquitin-associated domain
additional property: PropertyValue
  property ID: P637
  value: NP_038466
additional property: PropertyValue
  property ID: P637
  value: NP_444295
additional property: PropertyValue
  property ID: P637
  value: XP_005252005
additional property: PropertyValue
  property ID: P638
  value: 2JY5
additional property: PropertyValue
  property ID: P638
  value: 2JY6
additional property: PropertyValue
  property ID: P638
  value: 2KLC
additional property: PropertyValue
  property ID: P680
  value: polyubiquitin modification-dependent protein binding
additional property: PropertyValue
  property ID: P680
  value: kinase binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: aggrephagy
additional property: PropertyValue
  property ID: P682
  value: negative regulation of store-operated calcium channel activity
additional property: PropertyValue
  property ID: P682
  value: regulation of protein ubiquitination
additional property: PropertyValue
  property ID: P702
  value: UBQLN1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000257468
additional property: PropertyValue
  property ID: P705
  value: ENSP00000365576
additional property: PropertyValue
  property ID: P705
  value: ENSP00000434194
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:Q9UMX0
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/Q9UMX0
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/Q9UMX0
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 36
      unique citations norm: 0.014
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 36
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9UMX0
    source count: 1
    confidence: 0.2
  P361:
    value: Q24722600
    source count: 1
    confidence: 0.2
    value label: UBA-like superfamily
  P361:
    value: Q24725964
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-like domain superfamily
  P361:
    value: Q83135045
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-associated domain, protein family
  P361:
    value: Q83166374
    source count: 1
    confidence: 0.2
    value label: Heat shock chaperonin-binding domain, protein family
  P361:
    value: Q83141069
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-like domain, protein family
  P527:
    value: Q24773826
    source count: 1
    confidence: 0.2
    value label: Ubiquitin domain
  P527:
    value: Q24787535
    source count: 1
    confidence: 0.2
    value label: Heat shock chaperonin-binding
  P527:
    value: Q24725609
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-associated domain
  P637:
    value: NP_038466
    source count: 1
    confidence: 0.2
  P637:
    value: NP_444295
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005252005
    source count: 1
    confidence: 0.2
  P638:
    value: 2JY5
    source count: 1
    confidence: 0.2
  P638:
    value: 2JY6
    source count: 1
    confidence: 0.2
  P638:
    value: 2KLC
    source count: 1
    confidence: 0.2
  P680:
    value: Q21100451
    source count: 1
    confidence: 0.2
    value label: polyubiquitin modification-dependent protein binding
  P680:
    value: Q14864244
    source count: 1
    confidence: 0.2
    value label: kinase binding
  P680:
    value: Q167149
    source count: 20
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14762994
    source count: 3
    confidence: 0.6
    value label: identical protein binding

value: Q21100451
source count: 2
confidence: 0.4
value label: polyubiquitin modification-dependent protein binding

value: Q79899
source count: 4
confidence: 0.8
value label: cytoplasm

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q14817956
source count: 1
confidence: 0.2
value label: nucleoplasm

value: Q4692265
source count: 2
confidence: 0.4
value label: aggresome

value: Q21097582
source count: 1
confidence: 0.2
value label: aggrephagy

value: Q21115142
source count: 1
confidence: 0.2
value label: negative regulation of store-operated calcium channel activity

value: Q14906662
source count: 1
confidence: 0.2
value label: regulation of protein ubiquitination

value: Q21109016
source count: 1
confidence: 0.2
value label: regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

value: Q14875873
source count: 1
confidence: 0.2
value label: response to endoplasmic reticulum stress

value: Q18039745
source count: 1
confidence: 0.2
value label: UBQLN1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000257468
source count: 1
confidence: 0.2

value: ENSP00000365576
source count: 1
confidence: 0.2

value: ENSP00000434194
source count: 1
confidence: 0.2

value: ENSP00000436912
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:Q9UMX0
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/Q9UMX0
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/Q9UMX0
source count: 1
confidence: 0.2

source: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains
stated in qid: Q24293422
retrieved: 2018-09-10

source: Characterization of ubiquilin 1, an mTOR-interacting protein
stated in qid: Q24292327
retrieved: 2019-04-08

source: The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
stated in qid: Q24306610
retrieved: 2019-04-08

source: Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
stated in qid: Q24322965
retrieved: 2019-04-08

source: Herp enhances ER-associated protein degradation by recruiting ubiquilins
stated in qid: Q24318770
retrieved: 2019-04-08

source: Ubiquilin interacts with ubiquitylated proteins and proteasome through its ubiquitin-associated and ubiquitin-like domains
stated in qid: Q24293422
retrieved: 2019-04-08

source: Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
stated in qid: Q24314297
retrieved: 2019-04-08

source: Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction
stated in qid: Q24323148
retrieved: 2019-04-08

source: Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD
stated in qid: Q24324707
retrieved: 2019-04-08

source: Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization
stated in qid: Q24308010
retrieved: 2019-04-08

source: A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
stated in qid: Q24337490
retrieved: 2019-04-08

source: The UBL domain of PLIC-1 regulates aggresome formation
stated in qid: Q24311874
retrieved: 2019-04-08

source: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis
stated in qid: Q24294410
retrieved: 2019-04-08

source: Next-generation sequencing to generate interactome datasets
stated in qid: Q24300269
retrieved: 2019-04-08

source: Towards a proteome-scale map of the human protein–protein interaction network
stated in qid: Q21735930
retrieved: 2019-04-08

source: A proteome-scale map of the human interactome network
stated in qid: Q24307146
retrieved: 2019-04-08

source: Widespread macromolecular interaction perturbations in human genetic disorders
stated in qid: Q28771729
retrieved: 2019-04-08

source: Toward an understanding of the protein interaction network of the human liver
stated in qid: Q24292988
retrieved: 2019-04-08

source: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
stated in qid: Q36940515
retrieved: 2019-04-08

source: Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation
stated in qid: Q24290515
retrieved: 2019-04-08

source: Role of ubiquilin associated with protein-disulfide isomerase in the endoplasmic reticulum in stress-induced apoptotic cell death
stated in qid: Q24300869
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase
stated in qid: Q24297704
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery
stated in qid: Q24322965
retrieved: 2018-09-10

source: Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization
stated in qid: Q24308010
retrieved: 2018-09-10

source: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
stated in qid: Q24317381
retrieved: 2018-09-10

source: Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
stated in qid: Q24314297
retrieved: 2018-09-10

source: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
stated in qid: Q24317381
retrieved: 2019-04-08

wikidata id: Q21115143
domain: protein
level: standard
html url: https://4ort.xyz/entity/ubiquilin-1
markdown url: https://4ort.xyz/entity/ubiquilin-1.md
facts url summary: https://4ort.xyz/entity/ubiquilin-1/facts.json
facts url standard: https://4ort.xyz/entity/ubiquilin-1/facts.json
facts url full: https://4ort.xyz/entity/ubiquilin-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T05:07:08.124597Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z