# U4/U6-U5 snRNP complex subunit PRP8 YHR165C

> fungal protein found in Saccharomyces cerevisiae S288c

**Wikidata**: [Q27551093](https://www.wikidata.org/wiki/Q27551093)  
**Source**: https://4ort.xyz/entity/u4-u6-u5-snrnp-complex-subunit-prp8-yhr165c


## References

1. UniProt
2. Q20641742
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P33334)
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
5. [Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
6. [Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
8. [Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
9. [Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
10. [Crystal structure of Prp8 reveals active site cavity of the spliceosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
11. [Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
12. [Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
13. [Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
14. [Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
15. [prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
16. [Inhibition of RNA Helicase Brr2 by the C-Terminal Tail of the Spliceosomal Protein Prp8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
17. [Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
18. [New Roles for the Snp1 and Exo84 Proteins in Yeast Pre-mRNA Splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
19. [Proteome survey reveals modularity of the yeast cell machinery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
20. [ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
21. [Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
22. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
23. [Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
24. [Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
25. [Global analysis of yeast mRNPs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
26. [Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
27. [The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
28. [prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast](http://www.ebi.ac.uk/QuickGO/annotations?protein=P33334&geneProductId=UniProtKB:P33334)
29. [Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6·U5] tri‐snRNP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
30. [Purification of the yeast U4/U6⋅U5 small nuclear ribonucleoprotein particle and identification of its proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
31. [Biochemical and genetic analyses of the U5, U6, and U4/U6 x U5 small nuclear ribonucleoproteins from Saccharomyces cerevisiae](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
32. [The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
33. [Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
34. [CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
35. [Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
36. [Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
37. [Prp8 positioning of U5 snRNA is linked to 5' splice site recognition.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33334)
38. ensembl Release 106