# Tyrosine kinase non receptor 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21115284](https://www.wikidata.org/wiki/Q21115284)  
**Source**: https://4ort.xyz/entity/tyrosine-kinase-non-receptor-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q07912)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
6. [HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
7. [A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
8. [Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
9. [Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
10. [Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
11. [Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
12. [Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
13. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
15. [Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
16. [Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
17. [Purification and enzyme activity of ACK1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
18. [Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
20. [Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912)
22. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q07912&geneProductId=UniProtKB:Q07912)
23. [Regulation of Ack1 localization and activity by the amino-terminal SAM domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
24. [Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
25. [Dysregulation of Ack1 inhibits down-regulation of the EGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
26. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
27. [Ack kinase regulates CTP synthase filaments during Drosophila oogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
28. [Shepherding AKT and androgen receptor by Ack1 tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q07912)
29. ensembl Release 96