# Tyrosine hydroxylase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28557363](https://www.wikidata.org/wiki/Q28557363)  
**Source**: https://4ort.xyz/entity/tyrosine-hydroxylase-q28557363


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04177)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
5. [Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
6. [Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
7. [Measurement of intrinsic rate constants in the tyrosine hydroxylase reaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
8. [Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
10. [A biochemical and functional protein complex involving dopamine synthesis and transport into synaptic vesicles.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
11. [A role for alpha-synuclein in the regulation of dopamine biosynthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
12. [Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
13. [Reduction and oxidation of the active site iron in tyrosine hydroxylase: kinetics and specificity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
14. [Mutation of regulatory serines of rat tyrosine hydroxylase to glutamate: effects on enzyme stability and activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
15. [Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
16. [Isoosmotic isolation of rat brain synaptic vesicles, some of which contain tyrosine hydroxylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
17. [Sexual dimorphism in locus coeruleus dendritic morphology: a structural basis for sex differences in emotional arousal](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
18. [Dopaminergic Projections from Midbrain to Primary Motor Cortex Mediate Motor Skill Learning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
19. [Interactions between orexin-immunoreactive fibers and adrenaline or noradrenaline-expressing neurons of the lower brainstem in rats and mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
20. [Hypobaric hypoxia modulates brain biogenic amines and disturbs sleep architecture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
21. [Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
22. [Melatonin attenuates the amphetamine-induced decrease in vesicular monoamine transporter-2 expression in postnatal rat striatum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
23. [Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
24. [A single RNA species injected in Xenopus oocyte directs the synthesis of active tyrosine hydroxylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
25. [The effects of docosahexaenoic acid on glial derived neurotrophic factor and neurturin in bilateral rat model of Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
26. [Modulation of Sphingosine 1-Phosphate and Tyrosine Hydroxylase in the Stress-Induced Anxiety](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
27. [Developmental expression of δ‐opioid receptors during maturation of the parasympathetic, sympathetic, and sensory innervations of the neonatal heart: Early targets for opioid regulation of autonomic control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
28. [Tyrosine hydroxylase in rat auditory midbrain: distribution and changes following deafness](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
29. [Upregulation of neuronal nitric oxide synthase mRNA and protein in adrenal medulla of water-deprived rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
30. [Photoperiodic suppression of drug reinstatement](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
31. [Effect of zinc and paraquat co-exposure on neurodegeneration: Modulation of oxidative stress and expression of metallothioneins, toxicant responsive and transporter genes in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
32. [Vasopressinergic neurons of the supraoptic nucleus in perinatal rats: reaction to osmotic stimulation and its regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
33. [Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
34. [Aging of the rat mesostriatal system: differences between the nigrostriatal and the mesolimbic compartments](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
35. [Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
36. [Treadmill training improves motor skills and increases tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta in diabetic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
37. [Catalponol enhances dopamine biosynthesis and protects againstl-DOPA-induced cytotoxicity in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
38. [Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
39. [Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: Inhibition of proliferation and promotion of differentiation in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
40. [Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
41. [Moderate caloric restriction during gestation in rats alters adipose tissue sympathetic innervation and later adiposity in offspring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
42. [Estradiol stimulates gene expression of norepinephrine biosynthetic enzymes in rat locus coeruleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
43. [Cholecystokinin and hypothalamic corticotrophin-releasing factor participate in endotoxin-induced hypophagia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
44. [Effects of anonaine on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
45. [Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
46. [Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
47. [Effect of immobilization stress on gene expression of catecholamine biosynthetic enzymes in heart auricles of socially isolated rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
48. [Gene expression of catecholamine synthesizing enzymes in A5 cell group and modulation of tyrosine hydroxylase mRNA by immobilization stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
49. [Alterations in cognitive function and behavioral response to amphetamine induced by prenatal inflammation are dependent on the stage of pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)
50. [Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04177)