Two pore segment channel 2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: phosphatidyl (3,5) inositol biphosphate
additional property: PropertyValue
  property ID: P129
  value: verapamil
additional property: PropertyValue
  property ID: P361
  value: Two pore calcium channel protein 2
additional property: PropertyValue
  property ID: P361
  value: Voltage-dependent channel domain superfamily
additional property: PropertyValue
  property ID: P361
  value: voltage-gated ion channel
additional property: PropertyValue
  property ID: P527
  value: Ion transport domain
additional property: PropertyValue
  property ID: P637
  value: NP_620714
additional property: PropertyValue
  property ID: P680
  value: calcium channel activity
additional property: PropertyValue
  property ID: P680
  value: voltage-gated ion channel activity
additional property: PropertyValue
  property ID: P680
  value: ion channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: plasma membrane
additional property: PropertyValue
  property ID: P682
  value: release of sequestered calcium ion into cytosol
additional property: PropertyValue
  property ID: P682
  value: membrane depolarization during action potential
additional property: PropertyValue
  property ID: P682
  value: response to vitamin D
additional property: PropertyValue
  property ID: P702
  value: TPCN2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000294309
additional property: PropertyValue
  property ID: P705
  value: ENSP00000445551
additional property: PropertyValue
  property ID: P705
  value: ENSP00000489759
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:Q8NHX9
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/Q8NHX9
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/Q8NHX9
additional property: PropertyValue
  property ID: P7260
  value: 1.A.1.11.19
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 18
      unique citations norm: 0.007
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 18
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q3138518
    source count: 1
    confidence: 0.2
    value label: phosphatidyl (3,5) inositol biphosphate
  P129:
    value: Q410291
    source count: 1
    confidence: 0.2
    value label: verapamil
  P352:
    value: Q8NHX9
    source count: 1
    confidence: 0.2
  P361:
    value: Q32853555
    source count: 1
    confidence: 0.2
    value label: Two pore calcium channel protein 2
  P361:
    value: Q54444446
    source count: 1
    confidence: 0.2
    value label: Voltage-dependent channel domain superfamily
  P361:
    value: Q354550
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel
  P361:
    value: Q83138248
    source count: 1
    confidence: 0.2
    value label: Ion transport domain, protein family
  P527:
    value: Q24767982
    source count: 1
    confidence: 0.2
    value label: Ion transport domain
  P637:
    value: NP_620714
    source count: 1
    confidence: 0.2
  P680:
    value: Q14891583
    source count: 1
    confidence: 0.2
    value label: calcium channel activity
  P680:
    value: Q14865152
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel activity
  P680:
    value: Q14864714
    source count: 1
    confidence: 0.2
    value label: ion channel activity
  P680:
    value: Q167149
    source count: 3
    confidence: 0.6
    value label: protein binding
  P680:
    value: Q14762994
    source count: 1
    confidence: 0.2
    value label: identical protein binding
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane
  P681:
    value: Q14860543
    source count: 1
    confidence: 0.2
    value label: endosome membrane
  P681:
    value: Q83330
    source count: 3
    confidence: 0.6
    value label: lysosome
  P682:
    value: Q14885200
    source count: 1
    confidence: 0.2
    value label: release of sequestered calcium ion into cytosol

value: Q14905722
source count: 1
confidence: 0.2
value label: membrane depolarization during action potential

value: Q14599705
source count: 1
confidence: 0.2
value label: response to vitamin D

value: Q14865155
source count: 1
confidence: 0.2
value label: regulation of ion transmembrane transport

value: Q14633887
source count: 1
confidence: 0.2
value label: cellular calcium ion homeostasis

value: Q18053389
source count: 1
confidence: 0.2
value label: TPCN2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000294309
source count: 1
confidence: 0.2

value: ENSP00000445551
source count: 1
confidence: 0.2

value: ENSP00000489759
source count: 1
confidence: 0.2

value: ENSP00000490171
source count: 1
confidence: 0.2

value: ENSP00000490341
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:Q8NHX9
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/Q8NHX9
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/Q8NHX9
source count: 1
confidence: 0.2

value: 1.A.1.11.19
source count: 2
confidence: 0.4

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state
stated in qid: Q24315101
retrieved: 2019-04-08

source: Two-pore channels form homo- and heterodimers
stated in qid: Q24337485
retrieved: 2019-04-08

source: Hax-1 identified as a two-pore channel (TPC)-binding protein
stated in qid: Q24339389
retrieved: 2019-04-08

source: Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
stated in qid: Q24293723
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: NAADP mobilizes calcium from acidic organelles through two-pore channels
stated in qid: Q24318546
retrieved: 2018-07-16

source: Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
stated in qid: Q24316454
retrieved: 2018-07-16

source: NAADP mobilizes calcium from acidic organelles through two-pore channels
stated in qid: Q24318546
retrieved: 2019-04-08

source: Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
stated in qid: Q24316454
retrieved: 2019-04-08

source: Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition
stated in qid: Q24307004
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: Identifiers.org
stated in qid: Q16335163

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21103323
domain: protein
level: standard
html url: https://4ort.xyz/entity/two-pore-segment-channel-2
markdown url: https://4ort.xyz/entity/two-pore-segment-channel-2.md
facts url summary: https://4ort.xyz/entity/two-pore-segment-channel-2/facts.json
facts url standard: https://4ort.xyz/entity/two-pore-segment-channel-2/facts.json
facts url full: https://4ort.xyz/entity/two-pore-segment-channel-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T15:53:27.342891Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:47:25.717321+00:00Z