# Two pore segment channel 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21103323](https://www.wikidata.org/wiki/Q21103323)  
**Source**: https://4ort.xyz/entity/two-pore-segment-channel-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8NHX9)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
6. [mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
7. [Two-pore channels form homo- and heterodimers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
8. [Hax-1 identified as a two-pore channel (TPC)-binding protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
9. [Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NHX9&geneProductId=UniProtKB:Q8NHX9)
11. [NAADP mobilizes calcium from acidic organelles through two-pore channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NHX9&geneProductId=UniProtKB:Q8NHX9)
12. [Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NHX9&geneProductId=UniProtKB:Q8NHX9)
13. [NAADP mobilizes calcium from acidic organelles through two-pore channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
14. [Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
15. [Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NHX9)
16. Ensembl Release 99
17. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)
18. Transporter Classification database