Two pore segment channel 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: phosphatidyl (3,5) inositol biphosphate
additional property: PropertyValue
  property ID: P129
  value: verapamil
additional property: PropertyValue
  property ID: P361
  value: Two pore calcium channel protein 1
additional property: PropertyValue
  property ID: P361
  value: Voltage-dependent channel domain superfamily
additional property: PropertyValue
  property ID: P361
  value: voltage-gated ion channel
additional property: PropertyValue
  property ID: P527
  value: Ion transport domain
additional property: PropertyValue
  property ID: P637
  value: NP_001137291
additional property: PropertyValue
  property ID: P637
  value: NP_001288143
additional property: PropertyValue
  property ID: P637
  value: NP_060371
additional property: PropertyValue
  property ID: P680
  value: calcium channel activity
additional property: PropertyValue
  property ID: P680
  value: voltage-gated ion channel activity
additional property: PropertyValue
  property ID: P680
  value: ion channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: membrane depolarization during action potential
additional property: PropertyValue
  property ID: P682
  value: positive regulation of autophagy
additional property: PropertyValue
  property ID: P682
  value: regulation of ion transmembrane transport
additional property: PropertyValue
  property ID: P702
  value: TPCN1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000335300
additional property: PropertyValue
  property ID: P705
  value: ENSP00000438125
additional property: PropertyValue
  property ID: P705
  value: ENSP00000448083
additional property: PropertyValue
  property ID: P7260
  value: 1.A.1.11.25
confidence:
  popularity graph score:
    score: 0.002
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 15
      unique citations norm: 0.006
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 15
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q3138518
    source count: 1
    confidence: 0.2
    value label: phosphatidyl (3,5) inositol biphosphate
  P129:
    value: Q410291
    source count: 1
    confidence: 0.2
    value label: verapamil
  P352:
    value: Q9ULQ1
    source count: 1
    confidence: 0.2
  P361:
    value: Q28544076
    source count: 1
    confidence: 0.2
    value label: Two pore calcium channel protein 1
  P361:
    value: Q54444446
    source count: 1
    confidence: 0.2
    value label: Voltage-dependent channel domain superfamily
  P361:
    value: Q354550
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel
  P361:
    value: Q83138248
    source count: 1
    confidence: 0.2
    value label: Ion transport domain, protein family
  P527:
    value: Q24767982
    source count: 1
    confidence: 0.2
    value label: Ion transport domain
  P637:
    value: NP_001137291
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001288143
    source count: 1
    confidence: 0.2
  P637:
    value: NP_060371
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011536792
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011536794
    source count: 1
    confidence: 0.2
  P680:
    value: Q14891583
    source count: 1
    confidence: 0.2
    value label: calcium channel activity
  P680:
    value: Q14865152
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel activity
  P680:
    value: Q14864714
    source count: 1
    confidence: 0.2
    value label: ion channel activity
  P680:
    value: Q167149
    source count: 2
    confidence: 0.4
    value label: protein binding
  P680:
    value: Q14762994
    source count: 1
    confidence: 0.2
    value label: identical protein binding
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q824237
    source count: 2
    confidence: 0.4
    value label: endosome
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane

value: Q14878285
source count: 3
confidence: 0.6
value label: lysosomal membrane

value: Q14905722
source count: 1
confidence: 0.2
value label: membrane depolarization during action potential

value: Q14907694
source count: 1
confidence: 0.2
value label: positive regulation of autophagy

value: Q14865155
source count: 1
confidence: 0.2
value label: regulation of ion transmembrane transport

value: Q14859673
source count: 2
confidence: 0.4
value label: ion transport

value: Q14865154
source count: 1
confidence: 0.2
value label: ion transmembrane transport

value: Q18040620
source count: 1
confidence: 0.2
value label: TPCN1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000335300
source count: 1
confidence: 0.2

value: ENSP00000438125
source count: 1
confidence: 0.2

value: ENSP00000448083
source count: 1
confidence: 0.2

value: ENSP00000376350
source count: 1
confidence: 0.2

value: ENSP00000446767
source count: 1
confidence: 0.2

value: 1.A.1.11.25
source count: 2
confidence: 0.4

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Two-pore channels form homo- and heterodimers
stated in qid: Q24337485
retrieved: 2019-04-08

source: Hax-1 identified as a two-pore channel (TPC)-binding protein
stated in qid: Q24339389
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
stated in qid: Q24316454
retrieved: 2018-07-16

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2018-09-10

source: Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling
stated in qid: Q24316454
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
stated in qid: Q24293723
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21103337
domain: protein
level: standard
html url: https://4ort.xyz/entity/two-pore-segment-channel-1
markdown url: https://4ort.xyz/entity/two-pore-segment-channel-1.md
facts url summary: https://4ort.xyz/entity/two-pore-segment-channel-1/facts.json
facts url standard: https://4ort.xyz/entity/two-pore-segment-channel-1/facts.json
facts url full: https://4ort.xyz/entity/two-pore-segment-channel-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-23T18:23:37.615181Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:18.107337+00:00Z