Two pore channel 1
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Two pore calcium channel protein 1
additional property: PropertyValue
  property ID: P361
  value: Voltage-dependent channel domain superfamily
additional property: PropertyValue
  property ID: P361
  value: voltage-gated ion channel
additional property: PropertyValue
  property ID: P527
  value: Ion transport domain
additional property: PropertyValue
  property ID: P637
  value: NP_665852
additional property: PropertyValue
  property ID: P637
  value: XP_011246503
additional property: PropertyValue
  property ID: P637
  value: XP_030110373
additional property: PropertyValue
  property ID: P680
  value: NAADP-sensitive calcium-release channel activity
additional property: PropertyValue
  property ID: P680
  value: calcium channel activity
additional property: PropertyValue
  property ID: P680
  value: voltage-gated ion channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: endosome
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: membrane depolarization during action potential
additional property: PropertyValue
  property ID: P682
  value: regulation of ion transmembrane transport
additional property: PropertyValue
  property ID: P682
  value: ion transport
additional property: PropertyValue
  property ID: P702
  value: Tpcn1
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000042188
additional property: PropertyValue
  property ID: P7260
  value: 1.A.1.11.22
confidence:
  popularity graph score:
    score: 0.001
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 8
      unique citations norm: 0.003
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 8
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9EQJ0
    source count: 1
    confidence: 0.2
  P361:
    value: Q28544076
    source count: 1
    confidence: 0.2
    value label: Two pore calcium channel protein 1
  P361:
    value: Q54444446
    source count: 1
    confidence: 0.2
    value label: Voltage-dependent channel domain superfamily
  P361:
    value: Q354550
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel
  P361:
    value: Q83138248
    source count: 1
    confidence: 0.2
    value label: Ion transport domain, protein family
  P527:
    value: Q24767982
    source count: 1
    confidence: 0.2
    value label: Ion transport domain
  P637:
    value: NP_665852
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011246503
    source count: 1
    confidence: 0.2
  P637:
    value: XP_030110373
    source count: 1
    confidence: 0.2
  P637:
    value: XP_030110374
    source count: 1
    confidence: 0.2
  P680:
    value: Q14914271
    source count: 4
    confidence: 0.8
    value label: NAADP-sensitive calcium-release channel activity
  P680:
    value: Q14891583
    source count: 1
    confidence: 0.2
    value label: calcium channel activity
  P680:
    value: Q14865152
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel activity
  P680:
    value: Q14864714
    source count: 1
    confidence: 0.2
    value label: ion channel activity
  P680:
    value: Q14762994
    source count: 2
    confidence: 0.4
    value label: identical protein binding
  P681:
    value: Q14327652
    source count: 1
    confidence: 0.2
    value label: integral component of membrane
  P681:
    value: Q824237
    source count: 1
    confidence: 0.2
    value label: endosome
  P681:
    value: Q14349455
    source count: 2
    confidence: 0.4
    value label: membrane
  P681:
    value: Q29548
    source count: 1
    confidence: 0.2
    value label: plasma membrane
  P681:
    value: Q14878285
    source count: 4
    confidence: 0.8
    value label: lysosomal membrane
  P682:
    value: Q14905722
    source count: 1
    confidence: 0.2
    value label: membrane depolarization during action potential
  P682:
    value: Q14865155
    source count: 1
    confidence: 0.2
    value label: regulation of ion transmembrane transport
  P682:
    value: Q14859673
    source count: 2
    confidence: 0.4
    value label: ion transport
  P682:
    value: Q14891588
    source count: 1
    confidence: 0.2
    value label: calcium ion transmembrane transport

value: Q14820680
source count: 1
confidence: 0.2
value label: transmembrane transport

value: Q18299530
source count: 1
confidence: 0.2
value label: Tpcn1

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000042188
source count: 1
confidence: 0.2

value: 1.A.1.11.22
source count: 2
confidence: 0.4

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21991307
domain: protein
level: standard
html url: https://4ort.xyz/entity/two-pore-channel-1
markdown url: https://4ort.xyz/entity/two-pore-channel-1.md
facts url summary: https://4ort.xyz/entity/two-pore-channel-1/facts.json
facts url standard: https://4ort.xyz/entity/two-pore-channel-1/facts.json
facts url full: https://4ort.xyz/entity/two-pore-channel-1/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T01:30:18.161677Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:40:56.656023+00:00Z