# Twist family bHLH transcription factor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q575849](https://www.wikidata.org/wiki/Q575849)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Twist-related_protein_1)  
**Source**: https://4ort.xyz/entity/twist-family-bhlh-transcription-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q15672)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/H7C4D7)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:H7C4D7)
7. [HOXA5-twist interaction alters p53 homeostasis in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
8. [Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
9. [Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
10. [Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
11. [Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
12. [SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
13. [Twist and p53 reciprocally regulate target genes via direct interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
14. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
15. [In silico prediction of physical protein interactions and characterization of interactome orphans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
16. [Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
17. [A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
18. [Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
19. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
20. [TWIST inactivation reduces CBFA1/RUNX2 expression and DNA binding to the osteocalcin promoter in osteoblasts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
21. [A possible inflammatory role of twist1 in human white adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
22. [Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
23. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15672&geneProductId=UniProtKB:Q15672)
24. [The sonic hedgehog-patched-gli pathway in human development and disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
25. [Association of TWIST1 gene polymorphisms with bone mineral density in postmenopausal women](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
26. [Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
27. [Ocular phenotype correlations in patients with TWIST versus FGFR3 genetic mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
28. [Direct regulation of TWIST by HIF-1alpha promotes metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
29. [Twist negatively regulates osteoblastic differentiation in human periodontal ligament cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
30. [Up-regulation of Twist induces angiogenesis and correlates with metastasis in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
31. [Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
32. [Mutations of the TWIST gene in the Saethre-Chotzen syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
33. [Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
34. [Functional Analysis of Two Novel Mutations in TWIST1 Protein Motifs Found in Ventricular Septal Defect Patients](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15672)
35. Ensembl Release 99
36. Identifiers.org
37. UMLS 2023
38. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)