# tumor protein p53

> mammalian protein found in Homo sapiens

**Wikidata**: [Q283350](https://www.wikidata.org/wiki/Q283350)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/P53)  
**Source**: https://4ort.xyz/entity/tumor-protein-p53


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04637)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
6. [Source](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637)
7. [Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
8. [DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]](http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P04637)
9. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
10. [Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
11. [Homeobox Msx1 interacts with p53 tumor suppressor and inhibits tumor growth by inducing apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
12. [hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
13. [Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
14. [Aprataxin, a novel protein that protects against genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
15. [The Bloom syndrome protein interacts and cooperates with p53 in regulation of transcription and cell growth control](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
16. [Regulation of cellular response to oncogenic and oxidative stress by Seladin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
17. [RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
18. [p53 modulation of TFIIH–associated nucleotide excision repair activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
19. [p53 is regulated by the lysine demethylase LSD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
20. [Covalent and noncovalent modifiers of the p53 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
21. [NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
22. [MOZ increases p53 acetylation and premature senescence through its complex formation with PML](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
23. [Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
24. [Induction of SOX4 by DNA damage is critical for p53 stabilization and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
25. [RNF125 is a Ubiquitin-Protein Ligase that Promotes p53 Degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
26. [Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
27. [ASPP proteins specifically stimulate the apoptotic function of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
28. [The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
29. [ZNF385B is characteristically expressed in germinal center B cells and involved in B-cell apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
30. [Disruption of FAT10-MAD2 binding inhibits tumor progression.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
31. [USP10 regulates p53 localization and stability by deubiquitinating p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
32. [NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
33. [Molecular basis of Pirh2-mediated p53 ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
34. [CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
35. [p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
36. [NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
37. [The notch regulator MAML1 interacts with p53 and functions as a coactivator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
38. [Modulation of p53 function by SET8-mediated methylation at lysine 382](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
39. [Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
40. [Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
41. [Arginine methylation regulates the p53 response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
42. [NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
43. [p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
44. [High mobility group protein-1 (HMG-1) is a unique activator of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
45. [G9a and Glp methylate lysine 373 in the tumor suppressor p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
46. [Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
47. [Nucleophosmin regulates the stability and transcriptional activity of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
48. [Regulation of p53 tetramerization and nuclear export by ARC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
49. [The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)
50. [Repression of p53 activity by Smyd2-mediated methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04637)