# Tumor protein p53 binding protein 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21107570](https://www.wikidata.org/wiki/Q21107570)  
**Source**: https://4ort.xyz/entity/tumor-protein-p53-binding-protein-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12888)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
5. [p53 is regulated by the lysine demethylase LSD1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12888&geneProductId=UniProtKB:Q12888)
6. [p53 is regulated by the lysine demethylase LSD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
7. [Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
8. [A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
9. [Regulation of Chromatin Architecture by the PWWP Domain-Containing DNA Damage-Responsive Factor EXPAND1/MUM1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
10. [A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
11. [TIRR regulates 53BP1 by masking its histone methyl-lysine binding function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
12. [FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
13. [Accumulation of Pax2 Transactivation Domain Interaction Protein (PTIP) at Sites of DNA Breaks via RNF8-dependent Pathway Is Required for Cell Survival after DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
14. [Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
15. [PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
16. [Mutant p53 interactome identifies nardilysin as a p53R273H‐specific binding partner that promotes invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
17. [RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
18. [Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
19. [The BRCT-Domain Containing Protein PTIP Links PAX2 to a Histone H3, Lysine 4 Methyltransferase Complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
20. [Human PTIP Facilitates ATM-mediated Activation of p53 and Promotes Cellular Resistance to Ionizing Radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
21. [A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
22. [The phosphorylation status of PAS‐B distinguishes HIF‐1α from HIF‐2α in NBS1 repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
23. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
24. [RNF8‐ and RNF168‐dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
25. [Vaccinia-related Kinase 1 (VRK1) Is an Upstream Nucleosomal Kinase Required for the Assembly of 53BP1 Foci in Response to Ionizing Radiation-induced DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
26. [A new p38 MAP kinase‐regulated transcriptional coactivator that stimulates p53‐dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
27. [TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
28. [A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
29. [MDC1 is a mediator of the mammalian DNA damage checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
30. [ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
31. [DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
32. [A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G2/M DNA Damage Checkpoint](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
33. [Factors determining DNA double‐strand break repair pathway choice in G2 phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
34. [Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
35. [Tudor, MBT and chromo domains gauge the degree of lysine methylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
36. [A Proteome-Scale Map of the Human Interactome Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
37. [Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
38. [RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
39. [53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
40. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
41. [Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
42. [Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
43. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12888&geneProductId=UniProtKB:Q12888)
44. [TIRR regulates 53BP1 by masking its histone methyl-lysine binding function](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12888&geneProductId=UniProtKB:Q12888)
45. [Role of 53BP1 oligomerization in regulating double-strand break repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12888)
46. Ensembl Release 99