# tumor necrosis factor

> Human protein

**Wikidata**: [Q21173843](https://www.wikidata.org/wiki/Q21173843)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Tumor_necrosis_factor)  
**Source**: https://4ort.xyz/entity/tumor-necrosis-factor


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01375)
3. Q20641742
4. [Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
5. [Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
6. [The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
7. [Vaccinia virus CrmE encodes a soluble and cell surface tumor necrosis factor receptor that contributes to virus virulence](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
8. [Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
9. [Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
10. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
11. [Human tumor necrosis factor-alpha receptor. Purification by immunoaffinity chromatography and initial characterization](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
12. [Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
13. [Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
14. [Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
15. [Crystal structure of TNFα complexed with a poxvirus MHC-related TNF binding protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
16. [Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
17. [The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
18. [A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
19. [Structure of CrmE, a virus-encoded tumour necrosis factor receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
20. [A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
21. [Catalytic activity of ADAM8, ADAM15, and MDC-L (ADAM28) on synthetic peptide substrates and in ectodomain cleavage of CD23](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
22. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
23. [Inactivation of TNF signaling by rationally designed dominant-negative TNF variants](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
24. [A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
25. [Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
26. [Structure of tumour necrosis factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
27. [Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
28. [The shedding activity of ADAM17 is sequestered in lipid rafts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
29. [Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
30. [Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
31. [Pro/Anti-Inflammatory Cytokines in the Pathogenesis of Premature Coronary Artery Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
32. [Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
33. [RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
34. [Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
35. [Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
36. [AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
37. [Tumor necrosis factor-alpha induces vitamin D-1-hydroxylase activity in normal human alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
38. [Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
39. [Contrasting effects of IG20 and its splice isoforms, MADD and DENN-SV, on tumor necrosis factor alpha-induced apoptosis and activation of caspase-8 and -3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
40. [TNF-alpha inhibits HIV-1 replication in peripheral blood monocytes and alveolar macrophages by inducing the production of RANTES and decreasing C-C chemokine receptor 5 (CCR5) expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
41. [The Molecular Chaperone HSP70 Binds to and Stabilizes NOD2, an Important Protein Involved in Crohn Disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
42. [Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
43. [Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
44. [Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
45. [Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
46. [Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
47. [IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
48. [TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
49. [Interleukin-1beta and tumour necrosis factor-alpha impede neutral lipid turnover in macrophage-derived foam cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)
50. [Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01375&geneProductId=UniProtKB:P01375)