# Tumor necrosis factor

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556072](https://www.wikidata.org/wiki/Q28556072)  
**Source**: https://4ort.xyz/entity/tumor-necrosis-factor-q28556072


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P16599)
3. Q20641742
4. [Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
5. [Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
7. [14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
8. [Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
9. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
10. [Reduction of experimental necrotizing enterocolitis with anti-TNF-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
11. [Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET-1, TNF-alpha, and IL-1 alpha in LPS-induced rat intestinal microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
12. [The effect of transmembrane- and secreted-tumor necrosis factor-alpha on shock liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
13. [Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
14. [Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
15. [Effects of NF-kappaB oligonucleotide "decoys" on gene expression in P7 rat hippocampus after hypoxia/ischemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
16. [Cardiovascular and renal sympathetic activation by blood-borne TNF-alpha in rat: the role of central prostaglandins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
17. [TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
18. [Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
19. [Eccentric contraction induces inflammatory responses in rat skeletal muscle: role of tumor necrosis factor-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
20. [Tumor necrosis factor induces apoptosis in hepatoma cells by increasing Ca(2+) release from the endoplasmic reticulum and suppressing Bcl-2 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
21. [Diurnal variations of tumor necrosis factor alpha mRNA and alpha-tubulin mRNA in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
22. [Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
23. [Effect of electroacupuncture on the expression of spinal glial fibrillary acidic protein, tumor necrosis factor-alpha and interleukin-1beta in chronic neuropathic pain rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
24. [Differential expression of TNF-alpha, IL-6, and IGF-1 by graded mechanical stress in normal rat myocardium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
25. [Astrocyte galectin-9 potentiates microglial TNF secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
26. [TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
27. [Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-α inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
28. [beta(2)-adrenoceptor agonist suppresses renal tumour necrosis factor and enhances interleukin-6 gene expression induced by endotoxin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
29. [Age-associated impairment in vasorelaxation to fluid shear stress in the female vasculature is improved by TNF-alpha antagonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
30. [Short-term TNF-alpha inhibition reduces short-term and long-term inflammatory changes post-ischemia/reperfusion in rat intestinal transplantation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
31. [Tumor necrosis factor-alpha stimulates fractalkine production by mesangial cells and regulates monocyte transmigration: down-regulation by cAMP](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
32. [Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
33. [Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
34. [Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
35. [The mitogenic activity of the liver growth factor is mediated by tumor necrosis factor alpha in rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
36. [Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
37. [Control of synaptic strength by glial TNFalpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
38. [The role of tumor necrosis factor-alpha in the neuropathic pain induced by Lumbar 5 ventral root transection in rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
39. [Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
40. [Effects of Gold Nanoparticles on Endotoxin-Induced Uveitis in Rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
41. [Tumor necrosis factor-alpha stimulates cell proliferation in adipose tissue-derived stromal-vascular cell culture: promotion of adipose tissue expansion by paracrine growth factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
42. [Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16599)
43. ensembl Release 106