# Tumor necrosis factor, alpha-induced protein 3

> mammalian protein found in Mus musculus

**Wikidata**: [Q21991285](https://www.wikidata.org/wiki/Q21991285)  
**Source**: https://4ort.xyz/entity/tumor-necrosis-factor-alpha-induced-protein-3


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q60769)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
5. [The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
7. [Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
8. [ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
9. [The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
10. [Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
11. [Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
12. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
13. [The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
14. [T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
15. [Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60769&geneProductId=UniProtKB:Q60769)
17. [The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60769&geneProductId=UniProtKB:Q60769)
18. [B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
19. [A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
20. [The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
21. [A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
22. [Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
23. [The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
24. [Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
25. [A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
26. [Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
27. [A20 overexpression inhibits low shear flow-induced CD14-positive monocyte recruitment to endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
28. [TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60769)
29. ensembl Release 106