# TSC complex subunit 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21109261](https://www.wikidata.org/wiki/Q21109261)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/TSC2)  
**Source**: https://4ort.xyz/entity/tsc-complex-subunit-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49815)
3. Q20641742
4. [Docking motif-guided mapping of the interactome of protein phosphatase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
5. [Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
7. [The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
8. [The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
9. [WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
10. [Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
11. [p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
12. [Regulation of TSC2 by 14-3-3 binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
13. [Identification and characterization of the interaction between tuberin and 14-3-3zeta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
14. [Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
15. [Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
16. [IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
17. [Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
18. [PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
19. [Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
20. [SIRT1 negatively regulates the mammalian target of rapamycin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
21. [Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
22. [Tuberous sclerosis‐2 (TSC2) regulates the stability of death‐associated protein kinase‐1 (DAPK) through a lysosome‐dependent degradation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
23. [The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
24. [Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
25. [Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
26. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
27. [Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
28. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
29. [The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
30. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
31. [Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
32. [Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
33. [Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
34. [Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
35. [Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
36. [Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
37. [IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
38. [Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49815)
39. [IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49815&geneProductId=UniProtKB:P49815)
40. Ensembl Release 99
41. UMLS 2023
42. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)