# TSC complex subunit 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q898669](https://www.wikidata.org/wiki/Q898669)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/TSC1)  
**Source**: https://4ort.xyz/entity/tsc-complex-subunit-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q92574)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
6. [WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
7. [Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
8. [Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
9. [p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
10. [Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
11. [IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
12. [Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
13. [Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
14. [The TSC1 gene product hamartin interacts with NADE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
15. [Tuberous sclerosis‐2 (TSC2) regulates the stability of death‐associated protein kinase‐1 (DAPK) through a lysosome‐dependent degradation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
16. [The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
17. [The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
18. [The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
20. [Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
21. [Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
22. [Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
24. [TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
25. [Muscle atrophy in transgenic mice expressing a human TSC1 transgene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
26. [The TSC1 gene product, hamartin, negatively regulates cell proliferation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
27. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574)
28. [Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574)
29. [TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92574&geneProductId=UniProtKB:Q92574)
30. [The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
31. [Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92574)
32. Ensembl Release 99
33. UMLS 2023
34. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)