# Troponin I3, cardiac type

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21108986](https://www.wikidata.org/wiki/Q21108986)  
**Source**: https://4ort.xyz/entity/troponin-i3-cardiac-type


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19429)
3. Q20641742
4. [Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
5. [Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
6. [Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
7. [Polycystin-2 interacts with troponin I, an angiogenesis inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
8. [Troponin I binds polycystin-L and inhibits its calcium-induced channel activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
9. [Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
10. [LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
11. [Widespread macromolecular interaction perturbations in human genetic disorders](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
12. [TNNI3K is a novel mediator of myofilament function and phosphorylates cardiac troponin I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
13. [Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
14. [Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
15. [Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
16. [Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
17. [The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
18. [Functional Consequences of the Mutations in Human Cardiac Troponin I Gene Found in Familial Hypertrophic Cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
20. [A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
22. [Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
23. [Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
24. [Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
25. [Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
26. [Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
27. [Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
28. [Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
30. [Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
31. [Functional Consequences of the Mutations in Human Cardiac Troponin I Gene Found in Familial Hypertrophic Cardiomyopathy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19429&geneProductId=UniProtKB:P19429)
32. [Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19429)
33. Ensembl Release 99