# tripeptidyl peptidase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21136439](https://www.wikidata.org/wiki/Q21136439)  
**Source**: https://4ort.xyz/entity/tripeptidyl-peptidase-1-q21136439


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O14773)
3. Q20641742
4. [Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
5. [Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
6. [The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
7. [Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
8. [Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
10. [Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid Lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
11. [Neuronal ceroid lipofuscinoses are connected at molecular level: interaction of CLN5 protein with CLN2 and CLN3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
12. [Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
13. [Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
14. [Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
15. [The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
16. [Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
17. [Tripeptidyl peptidase I, the late infantile neuronal ceroid lipofuscinosis gene product, initiates the lysosomal degradation of subunit c of ATP synthase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
19. [Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
20. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
21. [Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
22. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
23. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
24. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
25. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
26. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
27. [Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco‐2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
28. [Purification and characterization of a tripeptidyl peptidase I from human osteoclastomas: evidence for its role in bone resorption](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
29. [Association of Mutations in a Lysosomal Protein with Classical Late-Infantile Neuronal Ceroid Lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=O14773&geneProductId=UniProtKB:O14773)
30. [Batten's disease: clues to neuronal protein catabolism in lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
31. [Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
32. [The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14773)
33. Ensembl Release 99
34. UMLS 2023