# Tripartite motif containing 21

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21103284](https://www.wikidata.org/wiki/Q21103284)  
**Source**: https://4ort.xyz/entity/tripartite-motif-containing-21


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P19474)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
5. [Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
6. [Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
7. [Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
8. [TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
9. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
10. [Systematic Analysis of Dimeric E3-RING Interactions Reveals Increased Combinatorial Complexity in Human Ubiquitination Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
11. [Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
12. [TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
14. [Autoantigen Ro52 is an E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
15. [UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
16. [The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
17. [Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
18. [Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
19. [Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system](http://www.ebi.ac.uk/QuickGO/annotations?protein=P19474&geneProductId=UniProtKB:P19474)
20. [UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
21. [The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
22. [Autoantigen Ro52 is an E3 ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
23. [Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
24. [Expression and DNA binding of the human 52 kDa Ro/SSA autoantigen](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
25. [Unique features of TRIM5alpha among closely related human TRIM family members](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
26. [TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
27. [TRIM E3 ligases interfere with early and late stages of the retroviral life cycle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19474)
28. Ensembl Release 99