# Triggering receptor expressed on myeloid cells 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21173956](https://www.wikidata.org/wiki/Q21173956)  
**Source**: https://4ort.xyz/entity/triggering-receptor-expressed-on-myeloid-cells-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NZC2)
3. Q20641742
4. [A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
6. [Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
7. [Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC2&geneProductId=UniProtKB:Q9NZC2)
8. [TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
9. [TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
10. [Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
11. [A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
12. [Intracellular trafficking of TREM2 is regulated by presenilin 1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
13. [TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
14. [An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
15. [Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
16. [TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZC2&geneProductId=UniProtKB:Q9NZC2)
18. [DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
19. [OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
20. [FRMD4A-cytohesin signaling modulates the cellular release of tau.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZC2)
21. Ensembl Release 99