# Transmembrane serine protease 6

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21126609](https://www.wikidata.org/wiki/Q21126609)  
**Source**: https://4ort.xyz/entity/transmembrane-serine-protease-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q8IU80)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
5. [Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
6. [Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80)
8. [Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
9. [Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80)
10. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
11. [Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80)
12. [Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IU80&geneProductId=UniProtKB:Q8IU80)
13. [Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IU80)
14. Ensembl Release 99