# Transmembrane immune signaling adaptor TYROBP

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21123076](https://www.wikidata.org/wiki/Q21123076)  
**Source**: https://4ort.xyz/entity/transmembrane-immune-signaling-adaptor-tyrobp-q21123076


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O43914)
3. Q20641742
4. [A Structural basis for the association of DAP12 with mouse, but not human, NKG2D](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43914&geneProductId=UniProtKB:O43914)
5. [A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43914&geneProductId=UniProtKB:O43914)
6. [Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
7. [Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
8. [Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
9. [NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
10. [NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
11. [A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
12. [A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
13. [Association of signal-regulatory proteins beta with KARAP/DAP-12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
14. [The structural basis for intramembrane assembly of an activating immunoreceptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
15. [Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
16. [TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
17. [A Structural basis for the association of DAP12 with mouse, but not human, NKG2D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O43914&geneProductId=UniProtKB:O43914)
20. [Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
21. [OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
22. [Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
23. [Essential role of DAP12 signaling in macrophage programming into a fusion-competent state](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
24. [DAP12 impacts trafficking and surface stability of killer immunoglobulin-like receptors on natural killer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
25. [DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
26. [The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O43914)
27. Ensembl Release 99
28. Transporter Classification database