Transient receptor potential cation channel subfamily C member 1
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: 2-aminoethoxydiphenylborate
additional property: PropertyValue
  property ID: P352
  value: P48995
additional property: PropertyValue
  property ID: P361
  value: Transient receptor potential channel, canonical 1
additional property: PropertyValue
  property ID: P361
  value: Ankyrin repeat-containing domain superfamily
additional property: PropertyValue
  property ID: P361
  value: transient receptor potential channel
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat-containing domain
additional property: PropertyValue
  property ID: P527
  value: Ion transport domain
additional property: PropertyValue
  property ID: P527
  value: ankyrin repeat
additional property: PropertyValue
  property ID: P637
  value: NP_001238774
additional property: PropertyValue
  property ID: P637
  value: NP_003295
additional property: PropertyValue
  property ID: P637
  value: XP_005247795
additional property: PropertyValue
  property ID: P680
  value: store-operated calcium channel activity
additional property: PropertyValue
  property ID: P680
  value: transmembrane transporter binding
additional property: PropertyValue
  property ID: P680
  value: calcium channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: receptor complex
additional property: PropertyValue
  property ID: P682
  value: melanin biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: regulation of cardiac conduction
additional property: PropertyValue
  property ID: P682
  value: regulation of cytosolic calcium ion concentration
additional property: PropertyValue
  property ID: P692
  value: PBB GE TRPC1 205803 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: TRPC1
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000481537
additional property: PropertyValue
  property ID: P705
  value: ENSP00000273482
additional property: PropertyValue
  property ID: P705
  value: ENSP00000419313
additional property: PropertyValue
  property ID: P7260
  value: 1.A.4.1.3
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 25
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 25
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q4596857
    source count: 1
    confidence: 0.2
    value label: 2-aminoethoxydiphenylborate
  P352:
    value: P48995
    source count: 1
    confidence: 0.2
  P361:
    value: Q24741637
    source count: 1
    confidence: 0.2
    value label: Transient receptor potential channel, canonical 1
  P361:
    value: Q41797869
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat-containing domain superfamily
  P361:
    value: Q304043
    source count: 1
    confidence: 0.2
    value label: transient receptor potential channel
  P361:
    value: Q83138248
    source count: 1
    confidence: 0.2
    value label: Ion transport domain, protein family
  P361:
    value: Q83146468
    source count: 1
    confidence: 0.2
    value label: Ankyrin repeat-containing domain, protein family
  P527:
    value: Q24778891
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat-containing domain
  P527:
    value: Q24767982
    source count: 1
    confidence: 0.2
    value label: Ion transport domain
  P527:
    value: Q24784174
    source count: 1
    confidence: 0.2
    value label: ankyrin repeat
  P527:
    value: Q24776056
    source count: 1
    confidence: 0.2
    value label: Transient receptor ion channel domain
  P637:
    value: NP_001238774
    source count: 1
    confidence: 0.2
  P637:
    value: NP_003295
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005247795
    source count: 1
    confidence: 0.2
  P637:
    value: XP_005247796
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016862610
    source count: 1
    confidence: 0.2
  P680:
    value: Q14911863
    source count: 1
    confidence: 0.2
    value label: store-operated calcium channel activity
  P680:
    value: Q14901685
    source count: 1
    confidence: 0.2
    value label: transmembrane transporter binding
  P680:
    value: Q14891583
    source count: 3
    confidence: 0.6
    value label: calcium channel activity
  P680:
    value: Q14914576
    source count: 1
    confidence: 0.2
    value label: inositol 1,4,5 trisphosphate binding

value: Q14864714
source count: 1
confidence: 0.2
value label: ion channel activity

value: Q14327652
source count: 2
confidence: 0.4
value label: integral component of membrane

value: Q14349455
source count: 2
confidence: 0.4
value label: membrane

value: Q14877465
source count: 1
confidence: 0.2
value label: receptor complex

value: Q29548
source count: 3
confidence: 0.6
value label: plasma membrane

value: Q14859540
source count: 1
confidence: 0.2
value label: integral component of plasma membrane

value: Q14865360
source count: 1
confidence: 0.2
value label: melanin biosynthetic process

value: Q21104937
source count: 1
confidence: 0.2
value label: regulation of cardiac conduction

value: Q14821006
source count: 1
confidence: 0.2
value label: regulation of cytosolic calcium ion concentration

value: Q14821004
source count: 1
confidence: 0.2
value label: positive regulation of release of sequestered calcium ion into cytosol

value: Q14859673
source count: 2
confidence: 0.4
value label: ion transport

value: PBB GE TRPC1 205803 s at fs.png
source count: 0
confidence: 0.0

value: Q15322678
source count: 1
confidence: 0.2
value label: TRPC1

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000481537
source count: 1
confidence: 0.2

value: ENSP00000273482
source count: 1
confidence: 0.2

value: ENSP00000419313
source count: 1
confidence: 0.2

value: ENSP00000418708
source count: 1
confidence: 0.2

value: 1.A.4.1.3
source count: 2
confidence: 0.4

source: Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion
stated in qid: Q28115710
retrieved: 2018-07-16

source: Specific association of the gene product of PKD2 with the TRPC1 channel
stated in qid: Q22009113
retrieved: 2018-01-01

source: trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry
stated in qid: Q24314989
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors
stated in qid: Q24295021
retrieved: 2018-07-16

source: Specific association of the gene product of PKD2 with the TRPC1 channel
stated in qid: Q22009113
retrieved: 2019-04-08

source: Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1.
stated in qid: Q30492038
retrieved: 2019-04-08

source: Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions
stated in qid: Q33847729
retrieved: 2019-04-08

source: Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells
stated in qid: Q24321234
retrieved: 2019-04-08

source: Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors
stated in qid: Q24295021
retrieved: 2019-04-08

source: STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction
stated in qid: Q28115928
retrieved: 2019-04-08

source: Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion
stated in qid: Q28115710
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins
stated in qid: Q24314344
retrieved: 2019-04-08

source: TRPC1, a human homolog of a Drosophila store-operated channel
stated in qid: Q24312092
retrieved: 2018-07-16

source: TRPC1, a human homolog of a Drosophila store-operated channel
stated in qid: Q24312092
retrieved: 2019-04-08

source: Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes
stated in qid: Q24336397
retrieved: 2019-04-08

source: Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells
stated in qid: Q24321234
retrieved: 2018-07-16

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q7671460
domain: protein
level: standard
html url: https://4ort.xyz/entity/transient-receptor-potential-cation-channel-subfamily-c-member-1-q7671460
markdown url: https://4ort.xyz/entity/transient-receptor-potential-cation-channel-subfamily-c-member-1-q7671460.md
facts url summary: https://4ort.xyz/entity/transient-receptor-potential-cation-channel-subfamily-c-member-1-q7671460/facts.json
facts url standard: https://4ort.xyz/entity/transient-receptor-potential-cation-channel-subfamily-c-member-1-q7671460/facts.json
facts url full: https://4ort.xyz/entity/transient-receptor-potential-cation-channel-subfamily-c-member-1-q7671460/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-10T20:31:23.501454Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:08:57.947351+00:00Z