# Transforming growth factor, beta receptor I

> mammalian protein found in Mus musculus

**Wikidata**: [Q14911575](https://www.wikidata.org/wiki/Q14911575)  
**Source**: https://4ort.xyz/entity/transforming-growth-factor-beta-receptor-i


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q64729)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
5. [Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
7. [Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
8. [Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
9. [Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
10. [Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
11. [SNX25 regulates TGF-β signaling by enhancing the receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
12. [RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
13. [Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
14. [LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
15. [Stem cell antigen-1 enhances tumorigenicity by disruption of growth differentiation factor-10 (GDF10)–dependent TGF-β signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
16. [ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
17. [TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
18. [TGF-beta signaling specifies axons during brain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
19. [Dlg5 interacts with the TGF-β receptor and promotes its degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
20. [VE-cadherin is a critical endothelial regulator of TGF-beta signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
21. [Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
22. [Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
23. [Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
25. [SNX25 regulates TGF-β signaling by enhancing the receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
26. [Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
27. [Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
28. [Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
29. [Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
30. [Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
31. [Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
32. [Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
33. [Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
34. [Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
35. [Identification of two distinct functions for TGF-beta in early mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
36. [Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
37. [Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-β in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
38. [Transforming growth factor beta 2 promotes the formation of the mouse cochleovestibular ganglion in organ culture](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
39. [Signaling via the Tgf-beta type I receptor Alk5 in heart development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
40. [Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-β in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
41. [Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
42. [Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
43. [Signaling via the Tgf-beta type I receptor Alk5 in heart development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
44. [Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64729&geneProductId=UniProtKB:Q64729)
45. [Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64729)
46. ensembl Release 106