# transforming growth factor beta receptor 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7670160](https://www.wikidata.org/wiki/Q7670160)  
**Source**: https://4ort.xyz/entity/transforming-growth-factor-beta-receptor-1-q7670160


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P36897)
3. Q20641742
4. [TGF beta signals through a heteromeric protein kinase receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
5. [Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
6. [Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
7. [Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
8. [TGF beta signals through a heteromeric protein kinase receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
10. [SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
11. [Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
12. [Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
14. [SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
15. [Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
16. [Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
17. [MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
18. [Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
19. [Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
20. [Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
21. [Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
22. [APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
23. [USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
24. [Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
25. [The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
26. [HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
27. [Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
28. [Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
29. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
30. [14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
31. [Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
32. [Activation of signalling by the activin receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
33. [Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
34. [Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
35. [Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
36. [S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
37. [Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
38. [Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
39. [TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
40. [MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
41. [SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
42. [Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
43. [SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
44. [Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
45. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
46. [MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
47. [TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
48. [MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)
49. [Receptor-associated Mad homologues synergize as effectors of the TGF-beta response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P36897&geneProductId=UniProtKB:P36897)
50. [Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36897)