# transforming growth factor beta 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2062543](https://www.wikidata.org/wiki/Q2062543)  
**Source**: https://4ort.xyz/entity/transforming-growth-factor-beta-1-q2062543


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P01137)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [TGF beta signals through a heteromeric protein kinase receptor complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
6. [Cloning and developmental expression of the chick type II and type III TGF beta receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
7. [Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
9. [HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
10. [Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
11. [Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
12. [Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
13. [Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
14. [Agrin binds BMP2, BMP4 and TGFbeta1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
15. [Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
16. [Extracellular heat shock protein HSP90beta secreted by MG63 osteosarcoma cells inhibits activation of latent TGF-beta1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
17. [Mechanisms for asporin function and regulation in articular cartilage](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
18. [Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
19. [Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
20. [DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
21. [Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
22. [SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
23. [Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
24. [WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
25. [Induction and Activation of Latent Transforming Growth Factor-β1 Are Carried out by Two Distinct Domains of Pregnancy-specific Glycoprotein 1 (PSG1)](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
26. [Latent TGF-β structure and activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
27. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
28. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
29. [A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
30. [Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
31. [Betaglycan binds inhibin and can mediate functional antagonism of activin signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
32. [Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
33. [The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
34. [TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
35. [Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
36. [SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
37. [Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
38. [Poly(ADP-ribose) Polymerase 1 Is Indispensable for Transforming Growth Factor-β Induced Smad3 Activation in Vascular Smooth Muscle Cell](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
39. [Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
40. [Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
41. [Opposite regulation of transforming growth factors-beta2 and -beta3 expression in the human endometrium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
42. [Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
43. [Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
44. [Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
45. [Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
46. [Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
47. [Bone morphogenetic proteins and growth and differentiation factors in the human cornea](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
48. [TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
49. [Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)
50. [Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P01137&geneProductId=UniProtKB:P01137)