# Transforming growth factor, beta 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q14904616](https://www.wikidata.org/wiki/Q14904616)  
**Source**: https://4ort.xyz/entity/transforming-growth-factor-beta-1-q14904616


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P04202)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
5. [Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
6. [Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
7. [Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
8. [Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
9. [The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
10. [P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
11. [Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
12. [Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
13. [Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
14. [Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
15. [Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
16. [Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
17. [A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
18. [Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
19. [Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
20. [T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
21. [Identification of two distinct functions for TGF-beta in early mouse development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
22. [Smad expression during kidney development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
23. [Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
24. [Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
25. [Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
26. [Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
27. [LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling.](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
28. [Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
29. [The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
30. [Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
31. [CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
32. [The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
33. [Wnt5a is required for proper mammary gland development and TGF-beta-mediated inhibition of ductal growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
34. [mSmile is Necessary for Bronchial Smooth Muscle and Alveolar Myofibroblast Development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
35. [TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
36. [The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
37. [Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
38. [TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
39. [IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
40. [Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
41. [TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
42. [Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
43. [Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
44. [Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
45. [TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
46. [Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
47. [EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
48. [The anaphase-promoting complex coordinates initiation of lens differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
49. [Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)
50. [Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P04202&geneProductId=UniProtKB:P04202)