# Transformation related protein 53

> mammalian protein found in Mus musculus

**Wikidata**: [Q14818136](https://www.wikidata.org/wiki/Q14818136)  
**Source**: https://4ort.xyz/entity/transformation-related-protein-53


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P02340)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
5. [Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
6. [SEI family of nuclear factors regulates p53-dependent transcriptional activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
7. [TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
8. [Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340)
9. [Pierce1, a Novel p53 Target Gene Contributing to the Ultraviolet-Induced DNA Damage Response](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340)
10. [SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340)
11. [A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
12. [p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
13. [Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P02340&geneProductId=UniProtKB:P02340)
15. [Trim24 targets endogenous p53 for degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
16. [Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
17. [PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
18. [PUMA couples the nuclear and cytoplasmic proapoptotic function of p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
19. [Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
20. [Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
21. [Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
22. [Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
23. [Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
24. [topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
25. [p53 opens the mitochondrial permeability transition pore to trigger necrosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
26. [Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
27. [Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
28. [GATA-1 associates with and inhibits p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
29. [Hsp70 family member, mot-2/mthsp70/GRP75, binds to the cytoplasmic sequestration domain of the p53 protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
30. [Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
31. [The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
32. [AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
33. [The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
34. [Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
35. [Deletion of Swm2p selectively impairs trimethylation of snRNAs by trimethylguanosine synthase (Tgs1p).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
36. [Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
37. [Naked cuticle targets dishevelled to antagonize Wnt signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
38. [Hepatitis C virus core protein interacts with a human DEAD box protein DDX3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
39. [The AKT3 potassium channel protein interacts with the AtPP2CA protein phosphatase 2C](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
40. [An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
41. [Binding and modulation of p53 by p300/CBP coactivators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
42. [Involvement of PTEN in TPA‐mediated p53‐activation in mouse skin epidermal JB6 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
43. [Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
44. [Design and application of a cytokine-receptor-based interaction trap](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
45. [A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
46. [p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
47. [Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
48. [A Pin1/mutant p53 axis promotes aggressiveness in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
49. [Interaction of Sesbania mosaic virus movement protein with the coat protein – implications for viral spread](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)
50. [Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02340)