# Transcription factor AP-2, alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q21982739](https://www.wikidata.org/wiki/Q21982739)  
**Source**: https://4ort.xyz/entity/transcription-factor-ap-2-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P34056)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
5. [Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
6. [Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
8. [Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
9. [Cloning and characterization of a second AP-2 transcription factor: AP-2 beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
10. [AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
11. [Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
12. [Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
13. [AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
14. [Cloning and characterization of a second AP-2 transcription factor: AP-2 beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
15. [Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
16. [AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
17. [AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
18. [Induction of dystrophin Dp71 expression during neuronal differentiation: opposite roles of Sp1 and AP2alpha in Dp71 promoter activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
19. [A Heart-Hand Syndrome Gene: Tfap2b Plays a Critical Role in the Development and Remodeling of Mouse Ductus Arteriosus and Limb Patterning](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
20. [Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
21. [Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
22. [A Heart-Hand Syndrome Gene: Tfap2b Plays a Critical Role in the Development and Remodeling of Mouse Ductus Arteriosus and Limb Patterning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
23. [Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
24. [High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
27. [Tbx3 is required for outflow tract development](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
28. [Cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
29. [Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
30. [AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
31. [AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
32. [Ectopic expression of luteinizing hormone-releasing hormone and peripherin in the respiratory epithelium of mice lacking transcription factor AP-2alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
33. [Tbx3 is required for outflow tract development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
34. [The transcription factors AP-2β and AP-2α are required for survival of sympathetic progenitors and differentiated sympathetic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
35. [Transcription factor AP-2 essential for cranial closure and craniofacial development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
36. [Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
37. [Loss of AP-2alpha impacts multiple aspects of ventral body wall development and closure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
38. [Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P34056&geneProductId=UniProtKB:P34056)
39. [Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
40. [Requirement for AP-2α in cardiac outflow tract morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
41. [Transcription factor activator protein-2 is required for continued luteinizing hormone-releasing hormone expression in the forebrain of developing mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
42. [AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
43. [AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
44. [AP-2alpha transcription factor is required for early morphogenesis of the lens vesicle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
45. [Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
46. [Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
47. [Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P34056)
48. ensembl Release 106