transcription factor 7 like 2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Catenin binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: High mobility group box domain superfamily
additional property: PropertyValue
  property ID: P361
  value: High mobility group box domain, protein family
additional property: PropertyValue
  property ID: P486
  value: D058118
additional property: PropertyValue
  property ID: P527
  value: CTNNB1 binding, N-teminal
additional property: PropertyValue
  property ID: P527
  value: High mobility group box domain
additional property: PropertyValue
  property ID: P637
  value: NP_001139746
additional property: PropertyValue
  property ID: P637
  value: NP_001139755
additional property: PropertyValue
  property ID: P637
  value: NP_001139756
additional property: PropertyValue
  property ID: P638
  value: 2GL7
additional property: PropertyValue
  property ID: P638
  value: 1JDH
additional property: PropertyValue
  property ID: P638
  value: 1JPW
additional property: PropertyValue
  property ID: P672
  value: D12.776.260.730.875
additional property: PropertyValue
  property ID: P672
  value: D12.776.660.235.400.800.875
additional property: PropertyValue
  property ID: P672
  value: D12.776.664.235.400.800.875
additional property: PropertyValue
  property ID: P680
  value: sequence-specific DNA binding
additional property: PropertyValue
  property ID: P680
  value: DNA binding
additional property: PropertyValue
  property ID: P680
  value: beta-catenin binding
additional property: PropertyValue
  property ID: P681
  value: beta-catenin-TCF7L2 complex
additional property: PropertyValue
  property ID: P681
  value: PML body
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P682
  value: positive regulation of heparan sulfate proteoglycan biosynthetic process
additional property: PropertyValue
  property ID: P682
  value: positive regulation of protein kinase B signaling
additional property: PropertyValue
  property ID: P682
  value: regulation of transcription, DNA-templated
additional property: PropertyValue
  property ID: P692
  value: PBB GE TCF7L2 212759 s at fs.png
additional property: PropertyValue
  property ID: P702
  value: TCF7L2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000486891
additional property: PropertyValue
  property ID: P705
  value: ENSP00000344823
confidence:
  popularity graph score:
    score: 0.008
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 61
      unique citations norm: 0.024
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 61
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9NQB0
    source count: 1
    confidence: 0.2
  P361:
    value: Q24726516
    source count: 1
    confidence: 0.2
    value label: Catenin binding domain superfamily
  P361:
    value: Q41798006
    source count: 1
    confidence: 0.2
    value label: High mobility group box domain superfamily
  P361:
    value: Q83139932
    source count: 1
    confidence: 0.2
    value label: High mobility group box domain, protein family
  P361:
    value: Q83165915
    source count: 1
    confidence: 0.2
    value label: CTNNB1 binding, N-teminal, protein family
  P486:
    value: D058118
    source count: 0
    confidence: 0.0
  P527:
    value: Q24786813
    source count: 1
    confidence: 0.2
    value label: CTNNB1 binding, N-teminal
  P527:
    value: Q24770625
    source count: 1
    confidence: 0.2
    value label: High mobility group box domain
  P637:
    value: NP_001139746
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001139755
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001139756
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001139757
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001139758
    source count: 1
    confidence: 0.2
  P638:
    value: 2GL7
    source count: 1
    confidence: 0.2
  P638:
    value: 1JDH
    source count: 1
    confidence: 0.2
  P638:
    value: 1JPW
    source count: 1
    confidence: 0.2
  P672:
    value: D12.776.260.730.875
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.660.235.400.800.875
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.664.235.400.800.875
    source count: 0
    confidence: 0.0
  P672:
    value: D12.776.930.875.875
    source count: 0
    confidence: 0.0

value: Q14818107
source count: 2
confidence: 0.4
value label: sequence-specific DNA binding

value: Q14633858
source count: 1
confidence: 0.2
value label: DNA binding

value: Q14872998
source count: 4
confidence: 0.8
value label: beta-catenin binding

value: Q14883314
source count: 1
confidence: 0.2
value label: gamma-catenin binding

value: Q14817979
source count: 1
confidence: 0.2
value label: DNA-binding transcription factor activity

value: Q14902670
source count: 2
confidence: 0.4
value label: beta-catenin-TCF7L2 complex

value: Q14817968
source count: 1
confidence: 0.2
value label: PML body

value: Q14817956
source count: 2
confidence: 0.4
value label: nucleoplasm

value: Q14888035
source count: 1
confidence: 0.2
value label: protein-DNA complex

value: Q40260
source count: 5
confidence: 1.0
value label: nucleus

value: Q14902761
source count: 1
confidence: 0.2
value label: positive regulation of heparan sulfate proteoglycan biosynthetic process

value: Q14761970
source count: 1
confidence: 0.2
value label: positive regulation of protein kinase B signaling

value: Q14633883
source count: 1
confidence: 0.2
value label: regulation of transcription, DNA-templated

value: Q14758934
source count: 1
confidence: 0.2
value label: glucose homeostasis

value: Q14852032
source count: 2
confidence: 0.4
value label: regulation of transcription by RNA polymerase II

value: PBB GE TCF7L2 212759 s at fs.png
source count: 0
confidence: 0.0

value: Q14913892
source count: 1
confidence: 0.2
value label: TCF7L2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000486891
source count: 1
confidence: 0.2

value: ENSP00000344823
source count: 1
confidence: 0.2

value: ENSP00000347949
source count: 1
confidence: 0.2

value: ENSP00000348274
source count: 1
confidence: 0.2

value: ENSP00000358404
source count: 1
confidence: 0.2

value: C0537423
source count: 1
confidence: 0.2

source: Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer
stated in qid: Q24307736
retrieved: 2018-06-21

source: Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line
stated in qid: Q24301381
retrieved: 2018-06-21

source: GOA
stated in qid: Q28018111
retrieved: 2018-01-01

source: ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules
stated in qid: Q24314463
retrieved: 2018-06-21

source: MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation
stated in qid: Q24310703
retrieved: 2018-06-21

source: GOA
stated in qid: Q28018111
retrieved: 2018-06-21

source: Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
stated in qid: Q24336272
retrieved: 2018-06-21

source: Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line
stated in qid: Q24301381
retrieved: 2018-01-01

source: Identification of c- MYC as a Target of the APC Pathway
stated in qid: Q24310637
retrieved: 2018-06-21

source: Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
stated in qid: Q24307491
retrieved: 2018-01-01

source: MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation
stated in qid: Q24310703
retrieved: 2018-01-01

source: Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1
stated in qid: Q24338569
retrieved: 2018-01-01

source: TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
stated in qid: Q24306440
retrieved: 2018-01-01

source: Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis
stated in qid: Q40084609
retrieved: 2018-01-01

source: XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling
stated in qid: Q24304410
retrieved: 2018-01-01

source: Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner
stated in qid: Q24293832
retrieved: 2018-01-01

source: Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis
stated in qid: Q37115261
retrieved: 2018-01-01

source: HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies
stated in qid: Q24337920
retrieved: 2018-01-01

source: Structure of a human Tcf4-beta-catenin complex
stated in qid: Q24291910
retrieved: 2018-01-01

source: The kinase TNIK is an essential activator of Wnt target genes
stated in qid: Q24323107
retrieved: 2018-01-01

source: Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
stated in qid: Q35607137
retrieved: 2018-01-01

source: Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.
stated in qid: Q33528931
retrieved: 2018-01-01

source: Tcf4 can specifically recognize beta-catenin using alternative conformations
stated in qid: Q24291909
retrieved: 2018-01-01

source: RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
stated in qid: Q24310469
retrieved: 2018-01-01

source: Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
stated in qid: Q24295533
retrieved: 2018-01-01

source: Bcr interferes with beta-catenin-Tcf1 interaction
stated in qid: Q24302316
retrieved: 2018-01-01

source: FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis
stated in qid: Q24293807
retrieved: 2018-01-01

source: Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells
stated in qid: Q24311467
retrieved: 2018-01-01

source: Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
stated in qid: Q24294207
retrieved: 2018-01-01

source: The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals
stated in qid: Q24302012
retrieved: 2018-01-01

wikidata id: Q14913880
domain: protein
level: standard
html url: https://4ort.xyz/entity/transcription-factor-7-like-2
markdown url: https://4ort.xyz/entity/transcription-factor-7-like-2.md
facts url summary: https://4ort.xyz/entity/transcription-factor-7-like-2/facts.json
facts url standard: https://4ort.xyz/entity/transcription-factor-7-like-2/facts.json
facts url full: https://4ort.xyz/entity/transcription-factor-7-like-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T14:03:25.953031Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:10:40.945259+00:00Z