# transcription factor 7 like 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q14913880](https://www.wikidata.org/wiki/Q14913880)  
**Source**: https://4ort.xyz/entity/transcription-factor-7-like-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9NQB0)
3. Q20641742
4. [Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
5. [Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
7. [ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
8. [MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
10. [Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
11. [Plakoglobin (gamma-catenin) has TCF/LEF family-dependent transcriptional activity in beta-catenin-deficient cell line](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
12. [Identification of c- MYC as a Target of the APC Pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
13. [Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
14. [MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
15. [Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
16. [TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
17. [Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
18. [XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
19. [Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
20. [Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
21. [HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
22. [Structure of a human Tcf4-beta-catenin complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
23. [The kinase TNIK is an essential activator of Wnt target genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
24. [Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
25. [Global regulator SATB1 recruits beta-catenin and regulates T(H)2 differentiation in Wnt-dependent manner.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
26. [Tcf4 can specifically recognize beta-catenin using alternative conformations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
27. [RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
28. [Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
29. [Bcr interferes with beta-catenin-Tcf1 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
30. [FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
31. [Physiological and functional interactions between Tcf4 and Daxx in colon cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
32. [Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
33. [The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF signals](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
34. [ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
35. [NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
36. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
37. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
38. [Identification of c- MYC as a Target of the APC Pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
39. [Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
40. [Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
41. [Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
42. [TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
43. [Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
44. [Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
45. [The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
46. [TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NQB0&geneProductId=UniProtKB:Q9NQB0)
47. [Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
48. [A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
49. [A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)
50. [Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NQB0)