# Transcription factor 7 like 2, T cell specific, HMG box

> mammalian protein found in Mus musculus

**Wikidata**: [Q14913903](https://www.wikidata.org/wiki/Q14913903)  
**Source**: https://4ort.xyz/entity/transcription-factor-7-like-2-t-cell-specific-hmg-box


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q924A0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
6. [Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
7. [Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
8. [HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
9. [HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
10. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
11. [Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
12. [A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
13. [TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
14. [Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
15. [The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
16. [Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
17. [TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
18. [HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
19. [Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
20. [A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
22. [Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
23. [The PDZ protein tax-interacting protein-1 inhibits beta-catenin transcriptional activity and growth of colorectal cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
24. [TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
25. [T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
26. [T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
27. [Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
28. [Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
29. [Alternative splicing of Tcf7l2 transcripts generates protein variants with differential promoter-binding and transcriptional activation properties at Wnt/beta-catenin targets](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
30. [TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
31. [Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
32. [T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
33. [T-cell factor 4N (TCF-4N), a novel isoform of mouse TCF-4, synergizes with beta-catenin to coactivate C/EBPalpha and steroidogenic factor 1 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
34. [Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
35. [Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
36. [A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
37. [TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
38. [Wnt signaling mediates regional specification in the vertebrate face](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
39. [Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
40. [Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
41. [Inhibition of adipogenesis by Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
42. [TCF4 deficiency expands ventral diencephalon signaling and increases induction of pituitary progenitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
43. [Connective tissue fibroblasts and Tcf4 regulate myogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
44. [Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
45. [TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
46. [Inhibition of adipogenesis by Wnt signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
47. [Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
48. [Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)
49. [Wnt signaling mediates regional specification in the vertebrate face](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q924A0&geneProductId=UniProtKB:Q924A0)
50. [Wnt signalling induces maturation of Paneth cells in intestinal crypts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q924A0)