# transcription factor 4

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7669683](https://www.wikidata.org/wiki/Q7669683)  
**Source**: https://4ort.xyz/entity/transcription-factor-4


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P15884)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
6. [Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
7. [Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
8. [The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
9. [The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
10. [HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
11. [Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
12. [The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
13. [Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
14. [Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
15. [Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
16. [Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
17. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
18. [Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
19. [In silico prediction of physical protein interactions and characterization of interactome orphans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
20. [miR-182-5p promotes hepatocellular carcinoma progression by repressing FOXO3a](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
21. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
22. [Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
23. [Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
24. [Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
25. [Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
26. [The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
27. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
28. [The cohesin SMC3 is a target the for beta-catenin/TCF4 transactivation pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
29. [Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
30. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
31. [Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
32. [HEB and E2A function as SMAD/FOXH1 cofactors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P15884&geneProductId=UniProtKB:P15884)
33. [Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
34. [HEB and E2A function as SMAD/FOXH1 cofactors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15884)
35. Ensembl Release 99
36. Identifiers.org
37. UMLS 2023